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β-Naphthoflavone

Product ID N0161
Cas No. 6051-87-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $111.90 In stock
5 g $356.40 In stock
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  • Description
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Description

β-Naphthoflavone is an agonist at the aryl hydrocarbon receptor and an inducer of phase II enzymes. β-Naphthoflavone exhibits anticancer and chemopreventive activities but also displays tumor-promoting activity in other models. In animal models, β-naphthoflavone inhibits cigarette smoke-induced DNA damage and tumor development. In breast cancer cells, this compound induces G0/G1 phase cell cycle arrest, downregulates expression of cyclin D1, cyclin D3, and CDK4, upregulates expression of p21, inhibits PI3K/Akt signaling, and activates MAPK/ERK signaling.

Product Info

Cas No.

6051-87-2

Purity

≥98%

Formula

C19H12O2

Formula Wt.

272.30

IUPAC Name

3-phenylbenzo[f]chromen-1-one

Synonym

5,6-Benzoflavone

Melting Point

164-166°C

Solubility

Slightly soluble in DMSO.

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

N0161 MSDS PDF

Info Sheet

N0161 Info Sheet PDF

References

Wang C, Xu CX, Bu Y, et al. Beta-naphthoflavone (DB06732) mediates estrogen receptor-positive breast cancer cell cycle arrest through AhR-dependent regulation of PI3K/AKT and MAPK/ERK signaling. Carcinogenesis. 2014 Mar;35(3):703-13. PMID: 24163404.

Tilton SC, Givan SA, Pereira CB, et al. Toxicogenomic profiling of the hepatic tumor promoters indole-3-carbinol, 17beta-estradiol and beta-naphthoflavone in rainbow trout. Toxicol Sci. 2006 Mar;90(1):61-72. PMID: 16192472.

Izzotti A, Bagnasco M, Cartiglia C, et al. Modulation of multigene expression and proteome profiles by chemopreventive agents. Mutat Res. 2005 Dec 11;591(1-2):212-23. PMID: 16083920.

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