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(±)-Warfarin

(±)-Warfarin

Product ID W0269
Cas No. 81-81-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $33.70 In stock
10 g $164.00 In stock
25 g $328.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Warfarin is an orally available antithrombotic commonly used for preventing blood clot formation and migration. The S enantiomer of warfarin is somewhat more potent than the R enantiomer. This coumarin inhibits the subunit 1 of the vitamin K epoxide reductase complex (VKORC1), depleting the reduced form of vitamin K (KH2) and inhibiting the formation of coagulation factors II, VII, IX, and X. Warfarin has a relatively slow onset and requires 1 to 2 days to take effect. This compound is highly sensitive to a wide variety of genetic polymorphisms and is metabolized by cytochrome P4502C9; it also interacts with many other medications and foods, requiring diligent activity monitoring.

Product Info

Cas No.

81-81-2

Purity

≥98%

Formula

C19H16O4

Formula Wt.

308.33

IUPAC Name

4-hydroxy-3-(3-oxo-1-phenylbutyl)chromen-2-one

Synonym

coumadin, Athrombine K, NSC 59813, (R,S)-Warfarin, WARF 42, Zoocoumarin, Coumafene

Melting Point

162.0 - 164.0

Solubility

Dioxane; Acetone Ether

Appearance

White powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

W0269 MSDS PDF

Info Sheet

W0269 Info Sheet PDF

Brochures

Warfarin Flyer

References

Hall AM, Wilkins MR. Warfarin: a case history in pharmacogenetics. Heart. 2005 May;91(5):563-4. PMID: 15831631.

Tabrizi AR, Zehnbauer BA, Borecki IB, et al. The frequency and effects of cytochrome P450 (CYP) 2C9 polymorphisms in patients receiving warfarin. J Am Coll Surg. 2002 Mar;194(3):267-73. PMID: 11893129.

Freedman MD. Oral anticoagulants: pharmacodynamics, clinical indications and adverse effects. J Clin Pharmacol. 1992 Mar;32(3):196-209. PMID:1564123.

Wallin R, Martin LF. Vitamin K-dependent carboxylation and vitamin K metabolism in liver. Effects of warfarin. J Clin Invest. 1985 Nov;76(5):1879-84. PMID: 3932474.

Suttie JW. Mechanism of action of vitamin K: demonstration of a liver precursor of prothrombin. Science. 1973 Jan 12;179(4069):192-4. PMID: 4682251.

Custom Order

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