LKT Labs

Biochemicals for Life Science Research

(−)-Epicatechin Gallate

(−)-Epicatechin Gallate

Product ID E6232
Cas No. 1257-08-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $52.00 In stock
5 mg $150.00 In stock
25 mg $325.00 In stock
Bulk Quote

Quicklinks

Description

(-)-Epicatechin gallate (ECG) is a flavanol/catechin originally found in Camilla and other plan sources; it exhibits antioxidative, neuromodulatory, anticancer, and anti-inflammatory activities. ECG displays agonist activity at cannabinoid 1 (CB1) receptors. ECG also inhibits expression of FLT3 and decreases phosphorylation of p38 MAPK, Akt, and STAT5 in acute myelogenous leukemia (AML) cells, suppressing cell proliferation. In vitro, this compound inhibits LPS- or peptidoglycan-induced production of VEGF and expression of COX-2.

Product Info

Cas No.

1257-08-5
Purity

≥98%
Formula

C22H18O10
Formula Wt.

442.37
Chemical Name

3,4,5-Trihydroxybenzoic acid, (2R,3R)-3,4- dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2-H-1-benzopyran-3-yl ester
IUPAC Name

[(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
Synonym

ECG
Melting Point

218°C

Solubility

Soluble in water or alcohol.
Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

E6232 MSDS PDF
Info Sheet

E6232 Info Sheet PDF
Brochures

Green Tea Flyer

Brochures

Natural Products Booklet

References

Nakanishi T, Mukai K, Hosokawa Y, et al. Catechins inhibit vascular endothelial growth factor production and cyclooxygenase-2 expression in human dental pulp cells. Int Endod J. 2014 May 21. [Epub ahead of print]. PMID: 24847951.

Ly BT, Chi HT, Yamagishi M, et al. Inhibition of FLT3 expression by green tea catechins in FLT3 mutated-AML cells. PLoS One. 2013 Jun 20;8(6):e66378. PMID: 23840454.

Korte G, Dreiseitel A, Schreier P, et al. Tea catechins' affinity for human cannabinoid receptors. Phytomedicine. 2010 Jan;17(1):19-22. PMID: 19897346.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • F0048

    Famciclovir

    Penciclovir prodrug, nucleoside (guanosine) ana...

    ≥98%
  • E6376

    Eptifibatide

    Glycoprotein IIb/IIIa inhibitor.

    ≥98%
  • P0254

    Panaxatriol

    Triterpene sapogenin found in species of Panax;...

    ≥98%
  • I5440

    INK128

    mTOR inhibitor.

    ≥99%
  • C9660

    Cypermethrin

    Synthetic type II pyrethroid insecticide; prote...

    ≥95%
  • P3076

    PHT-427

    PDK1 and Akt inhibitor.

    ≥98%
  • M002698

    M2698

    Dual inhibitor of p70S6K and Akt.

    ≥99%
  • A980005

    AZ-5104

    Inhibitor of EGFR.

    ≥98%
  • H1657

    Heparin-binding Peptide

    Peptide, binds heparin.

    ≥95%
  • A0933

    Acitretin

    Retinoid; RARα/β/γ agonist.

    ≥98%, multiple isomers
  • D3575

    2,5-Di-tert-butyl-4-hydroxyanisole

    BHA derivative; potential Ca2+ ATPase inhibitor...

    ≥98%
  • R0272

    Rasagiline Mesylate

    MAO-A/B inhibitor.

    ≥98%
  • M1879

    Metoprolol Tartrate

    β1-adrenergic antagonist.

    ≥98%
  • H000051

    H-151

    STING antagonist

    ≥99%
  • D3223

    Difloxacin Hydrochloride

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • P4403

    Plasminogen Activator Inhibitor 1

    Endogenous peptide, produced by activation of P...

    ≥95%
  • G3358

    Ginkgolide ABC

    Mixture of Ginkgolides A, B and C, found in Gin...

    ≥98%
  • S1971

    Sertraline Hydrochloride

    FIASMA, SERT and DAT inhibitor, α1-adrenergic ...

    ≥98%
  • E5211

    Endomorphin-2

    Endogenous opioid peptide; μOR agonist.

    ≥95%
  • D3201

    Diallyl Sulfide

    Organosulfur found in garlic.

    ≥98%