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(+)-JQ-1

(+)-JQ-1

Product ID J6400
Cas No. 1268524-70-4
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $85.20 In stock
5 mg $255.20 In stock
25 mg $781.10 In stock
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Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
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  • Custom Order

Description

JQ-1 is a triazolothienodiazepine compound that inhibits the BET bromodomain (BRD) family of proteins. Although it is a diazepine-like compound, JQ-1 exhibits no sedative or anxiolytic efficacy. JQ-1 was initially in development as a non-hormonal male contraceptive, inhibiting bromodomain testis-specific protein BRDT and chromatin remodeling during spermatogenesis, therefore preventing sperm production. This compound also activates latent HIV-1 in vitro and inhibits T cell proliferation through downregulation of T cell activation signals CD3, CD28, and CXCR4; JQ-1 is currently used as an experimental tool for examining mechanisms of HIV-1 latency. Additionally, JQ-1 exhibits anticancer chemotherapeutic activity in vitro and in vivo; through its inhibition of BRD4, JQ-1 suppresses Myc expression, IL-7R expression, and reduces JAK/STAT phosphorylation, inducing cell cycle arrest and altering survival in a variety of cell lines. Biological bromodomain binding activity comes primarily from (+)-JQ-1; the (-)-JQ-1 stereoisomer does not bind BET bromodomains.

Product Info

Cas No.

1268524-70-4

Purity

≥99%

Formula

C23H25ClN4O2S

Formula Wt.

456.99

IUPAC Name

tert-butyl 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate

Synonym

JQ1

Melting Point

109.5°C

Solubility

DMSO 91 mg/mL warmed (199.12 mM) Ethanol 91 mg/mL (199.12 mM) Water Insoluble

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

J6400 MSDS PDF

Info Sheet

J6400 Info Sheet PDF

References

Cinar M, Rosenfelt F, Rokhsar S, et al. Concurrent inhibition of MYC and BCL2 is a potentially effective treatment strategy for double hit and triple hit B-cell lymphomas. Leuk Res. 2015 Apr 17. [Epub ahead of print]. PMID: 25916698.

Da Costa D, Agathanggelou A, Perry T, et al. BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia. Blood Cancer J. 2013 Jul 19;3:e126. PMID: 23872705.

Ott CJ, Kopp N, Bird L, et al. BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia. Blood. 2012 Oct 4;120(14):2843-52. PMID: 22904298.

Banerjee C, Archin N, Michaels D, et al. BET bromodomain inhibition as a novel strategy for reactivation of HIV-1. J Leukoc Biol. 2012 Dec;92(6):1147-54. PMID: 22802445.

Zuber J, Shi J, Wang E, et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature. 2011 Aug 3;478(7370):524-8. PMID: 21814200.

Filippakopoulos P, Qi J, Picaud S, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73. PMID: 20871596.

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