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10,11-Dehydrocurvularin is a fungal metabolite produced by Penicillium species. 10,11-Dehydrocurvularin is a cyclic lactone that has been shown to interfere with NF-kB, JAK/STAT, and TGF-beta signalling. Furthermore, this macrocyclic polyketide has been found to be an activator of heat shock response and to produce immune-modulating activities.
| Cas No. | 1095588-70-7 |
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| Purity | ≥98% |
| Formula | C16H18O5 |
| Formula Wt. | 290.32 |
| Chemical Name | Dehydrocurvularin |
| IUPAC Name | (5S,9E)-13,15-dihydroxy-5-methyl-4-oxabicyclo[10.4.0]hexadeca-1(12),9,13,15-tetraene-3,11-dione  |
| Synonym | α,β-Dehydrocurvularin; Dehydrocurvularin; Trans-Dehydrocurvularin; AC1O5P3Y |
| Melting Point | 220-223°C |
| Appearance | White powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Ha TM, Ko W, Lee SJ, et al. Anti-inflammatory effects of curvularin-type metabolites form a marine-derived fungal strain Penicillium sp. SF-5859 in lipopolysaccharide-induced RAW264.7 macrophages. Mar Drugs. 2017 Sep 2;15(9):pii:E282. PMID: 28869509.
Schreiber D, Marx L, Felix S, et al. Anti-inflammatory effects of fungal metabolites in mouse intestine as revealed by in vitro models. Front Physiol. 2017 Aug 7;8:566. PMID: 28824460.
de Castro MV, Ioca LP, Williams DE, et al. Condensation of macrocyclic polyketides produced by Penicillium sp. DRF2 with mercaptopyruvate represents a new fungal detoxification pathway. J Nat Prod. 2016 Jun 24;79(6):1668-1678. PMID: 27227682.
Xu Y, Espinosa-Artiles P, Schubert V, et al. Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus. Appl Environ Microbiol. 2013 Mar;79(6):2038-2047. PMID: 23335766.
Rudolph K, Serwe A, Erkel G. Inhibition of TGF-beta signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclodecindione and galiellalactone. Cytokine, 2013 Jan;61(1):285-296. PMID: 23134667.