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10,11-Dehydrocurvularin

10,11-Dehydrocurvularin

Product ID D170310
Cas No. 1095588-70-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $115.90 In stock
5 mg $388.40 In stock
10 mg $674.60 In stock
Bulk Quote

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  • Description
  • Product Info
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  • References
  • Description
  • Product Info
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Description

10,11-Dehydrocurvularin is a fungal metabolite produced by Penicillium species. 10,11-Dehydrocurvularin is a cyclic lactone that has been shown to interfere with NF-kB, JAK/STAT, and TGF-beta signalling. Furthermore, this macrocyclic polyketide has been found to be an activator of heat shock response and to produce immune-modulating activities.

Product Info

Cas No.

1095588-70-7

Purity

≥98%

Formula

C16H18O5

Formula Wt.

290.32

Chemical Name

Dehydrocurvularin

IUPAC Name

(5S,9E)-13,15-dihydroxy-5-methyl-4-oxabicyclo[10.4.0]hexadeca-1(12),9,13,15-tetraene-3,11-dione  

Synonym

α,β-Dehydrocurvularin; Dehydrocurvularin; Trans-Dehydrocurvularin; AC1O5P3Y 

Melting Point

220-223°C

Appearance

White powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

D170310 MSDS PDF

Info Sheet

D170310 Info Sheet PDF

References

Ha TM, Ko W, Lee SJ, et al. Anti-inflammatory effects of curvularin-type metabolites form a marine-derived fungal strain Penicillium sp. SF-5859 in lipopolysaccharide-induced RAW264.7 macrophages. Mar Drugs. 2017 Sep 2;15(9):pii:E282. PMID: 28869509.

Schreiber D, Marx L, Felix S, et al. Anti-inflammatory effects of fungal metabolites in mouse intestine as revealed by in vitro models. Front Physiol. 2017 Aug 7;8:566. PMID: 28824460.

de Castro MV, Ioca LP, Williams DE, et al. Condensation of macrocyclic polyketides produced by Penicillium sp. DRF2 with mercaptopyruvate represents a new fungal detoxification pathway. J Nat Prod. 2016 Jun 24;79(6):1668-1678. PMID: 27227682.

Xu Y, Espinosa-Artiles P, Schubert V, et al. Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus. Appl Environ Microbiol. 2013 Mar;79(6):2038-2047. PMID: 23335766.

Rudolph K, Serwe A, Erkel G. Inhibition of TGF-beta signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclodecindione and galiellalactone. Cytokine, 2013 Jan;61(1):285-296. PMID: 23134667.

Custom Order

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