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1,4-DPCA

1,4-DPCA

Product ID D6108
Cas No. 331830-20-7
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $54.60 In stock
25 mg $223.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

1,4-DPCA is an inhibitor of prolyl hydroxylase that stabilizes expression of HIF-1α and exhibits anticancer and pro-angiogenic activities. In breast cancer cells, 1,4-DPCA inhibits cell proliferation and decreases deposition of collagens I and IV. This compound also limits growth of connective tissue on biomaterials and implanted medical devices.

Product Info

Cas No.

331830-20-7

Purity

≥98%

Formula

C13H8N2O3

Formula Wt.

240.22

Chemical Name

4,4alpha-dihydro-4-oxo-1,10-phenanthroline-3-carboxylic acid

IUPAC Name

4-Hydroxy-1,10-phenanthroline-3-carboxylic acid

Synonym

1,4-Dihydrophenonthrolin-4-one-3-carboxylic acid, 3-Acetyl-1H-[1,10]phenanthrolin-4-one

Solubility

Soluble in: DMSO (2.5 mg/mL, warm); ethanol (5 mg/mL, warm); DMF (5 mg/mL)

Appearance

Tan Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

D6108 MSDS PDF

Info Sheet

D6108 Info Sheet PDF

References

Zhang Y, Strehin I, Bedelbaeva K, et al. Drug-induced regeneration in adult mice. Sci Transl Med. 2015 Jun 3;7(290):290ra92. PMID: 26041709.

Xiong G, Deng L, Zhu J, et al. Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition. BMC Cancer. 2014 Jan 2;14:1. PMID: 24383403.

Love RJ, Jones KS. Transient inhibition of connective tissue infiltration and collagen deposition into porous poly(lactic-co-glycolic acid) discs. J Biomed Mater Res A. 2013 Dec;101(12):3599-606. PMID: 23766241.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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