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1,4-DPCA is an inhibitor of prolyl hydroxylase that stabilizes expression of HIF-1α and exhibits anticancer and pro-angiogenic activities. In breast cancer cells, 1,4-DPCA inhibits cell proliferation and decreases deposition of collagens I and IV. This compound also limits growth of connective tissue on biomaterials and implanted medical devices.
| Cas No. | 331830-20-7 |
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| Purity | ≥98% |
| Formula | C13H8N2O3 |
| Formula Wt. | 240.22 |
| Chemical Name | 4,4alpha-dihydro-4-oxo-1,10-phenanthroline-3-carboxylic acid |
| IUPAC Name | 4-Hydroxy-1,10-phenanthroline-3-carboxylic acid |
| Synonym | 1,4-Dihydrophenonthrolin-4-one-3-carboxylic acid, 3-Acetyl-1H-[1,10]phenanthrolin-4-one |
| Solubility | Soluble in: DMSO (2.5 mg/mL, warm); ethanol (5 mg/mL, warm); DMF (5 mg/mL) |
| Appearance | Tan Powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Zhang Y, Strehin I, Bedelbaeva K, et al. Drug-induced regeneration in adult mice. Sci Transl Med. 2015 Jun 3;7(290):290ra92. PMID: 26041709.
Xiong G, Deng L, Zhu J, et al. Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition. BMC Cancer. 2014 Jan 2;14:1. PMID: 24383403.
Love RJ, Jones KS. Transient inhibition of connective tissue infiltration and collagen deposition into porous poly(lactic-co-glycolic acid) discs. J Biomed Mater Res A. 2013 Dec;101(12):3599-606. PMID: 23766241.