• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
2-Hydroxyestradiol

2-Hydroxyestradiol

Product ID H9816
Cas No. 362-05-0
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $125.80 In stock
5 mg $440.60 In stock
10 mg $817.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

2-Hydroxy estradiol (2-OH E2) is a cytochrome P450 metabolite of estradiol with low affinity for estrogen receptors. 2-OH E2 exhibits anti-inflammatory, neuroprotective, mitogenic, and potentially anti-angiogenic activities. In vitro, 2-OH E2 decreases release of prostaglandin E2 (PGE2). In hippocampal HT22 cells, 2-OH E2 decreases cellular lipid peroxidation and cell death induced by hydrogen peroxide. Additionally, 2-OH E2 displays mitogenic effects on vascular smooth muscle cells after conversion to methoxyestradiols and catecholestradiols via cytochrome P450 and catechol-O-methyltransferase (COMT) enzymes. Similar compound 2-methoxy estradiol (2-ME2) has achieved considerable attention as an anticancer chemotherapeutic and anti-angiogenic agent through inhibition of the HIF-1α pathway.

Product Info

Cas No.

362-05-0

Purity

≥99%

Formula

C18H24O3

Formula Wt.

288.38

IUPAC Name

(8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16, 17-decahydrocyclopenta[a]phenanthrene-2,3,17-triol

Synonym

2-OH E2, NSC61711, 2-HE2

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

H9816 MSDS PDF

Info Sheet

H9816 Info Sheet PDF

References

Pavan B, Paganetto G, Dalpiaz A, et al. Estrogen metabolites in the release of inflammatory mediators from human amnion-derived cells. Life Sci. 2011 Mar 14;88(11-12):551-8. PMID: 21277863.

Becker CM, Rohwer N, Funakoshi T, et al. 2-methoxyestradiol inhibits hypoxia-inducible factor-1{alpha} and suppresses growth of lesions in a mouse model of endometriosis. Am J Pathol. 2008 Feb;172(2):534-44. PMID: 18202195.

Dubey RK, Jackson EK, Gillespie DG, et al. Catecholamines block the antimitogenic effect of estradiol on human coronary artery smooth muscle cells. J Clin Endocrinol Metab. 2004 Aug;89(8):3922-31. PMID: 15292328.

Zacharia LC, Piché CA, Fielding RM, et al. 2-hydroxyestradiol is a prodrug of 2-methoxyestradiol. J Pharmacol Exp Ther. 2004 Jun;309(3):1093-7. PMID: 14872091.

Teepker M, Anthes N, Krieg JC, et al. 2-OH-estradiol, an endogenous hormone with neuroprotective functions. J Psychiatr Res. 2003 Nov-Dec;37(6):517-23. PMID: 14563383.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • H9618

    Hydroquinone

    Basic phenol skeleton structure found in variou...

    ≥96%
  • A0963

    Adrenocorticotropic Hormone (1-10), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • L1786

    Levofloxacin Hydrochloride Monohydrate

    Fluoroquinolone, S-(-) isomer of ofloxacin; top...

    ≥90%
  • D8145

    Duloxetine Hydrochloride

    SERT and NET inhibitor, Nav1.7 Na+ channel bloc...

    ≥99%
  • A0819

    Acetylsalicylic Acid

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • D1874

    Desvenlafaxine Succinate Hydrate

    Venlafaxine metabolite; SERT and NET inhibitor....

    ≥99%
  • H978583

    Hyoscyamine sulfate dihydrate

    Tropane alkaloid found in plants in the Solanac...

    ≥99%
  • S0278

    Satraplatin

    Pt-based DNA cross-linker.

    ≥98%
  • M1444

    MDL 29951

    GPR17 agonist, NMDA and fructose 1,6-bisphospha...

    ≥98%
  • O4658

    Olopatadine Hydrochloride

    Mast cell stabilizer; histamine H1/2/3 antagoni...

    ≥99%
  • A0534

    Abiraterone

    Progesterone derivative; Cyp17A1 inhibitor.

    ≥99%
  • C9773

    L-Cystine

    Endogenous amino acid, forms disulfide bridges ...

    ≥98%
  • T1014

    7-TES-Paclitaxel

    Synthesis impurity

    ≥95%
  • D1777

    Desmopressin Acetate

    Synthetic peptide, vasopressin derivative; V2 a...

    ≥95%
  • O610291

    Ophiobolin A

    Tetracyclic sesterpenoid phytotoxin.

    ≥98%
  • U6857

    Urodilatin CCC

    ANP fragment, natriuretic peptide; Na+/K+ ATPas...

    ≥98%
  • O9322

    Oxfendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • B8261

    Bupivacaine

    BK/SK, Kv1, Kv3, TASK-2 K+ channel blocker, vol...

    ≥99%
  • E7376

    Estradiol

    Endogenous steroid hormone, involved in regulat...

    ≥97%
  • C0154

    7-Ethyl-10-hydroxycamptothecin

    Camptothecin derivative; topoisomerase I inhibi...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only