• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
2-Methoxyestradiol

2-Methoxyestradiol

Product ID M1678
Cas No. 362-07-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $49.00 In stock
10 mg $92.00 In stock
50 mg $337.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

2-Methoxyestradiol is a metabolite of estradiol that exhibits anti-angiogenic, vasodilatory, antihypertensive, anti-fibrotic, anticancer chemotherapeutic and chemopreventive activities. 2-Methoxyestradiol also displays antimitotic activity, binding the colchicine site of tubulin and disrupting the microtubule process during cell division. This compound decreases tumor growth, VEGF expression, and angiogenesis in animal models of hepatocellular carcinoma and prevents initial development of tumors in animal models of prostate cancer. In hypertensive rates, 2-methoxyestradiol decreases mean arterial blood pressure. Additionally, this compound inhibits TGF-β3-induced fibrosis in vitro, decreasing expression of collagen, PAI-1, CTGF, and α-SMA and preventing phosphorylation of Smad2/3.

Product Info

Cas No.

362-07-2

Purity

≥98%

Formula

C19H26O3

Formula Wt.

302.41

IUPAC Name

(8R,9S,13S,14S,17S)-2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16, 17-decahydrocyclopenta[a]phenanthrene-3,17-diol

Synonym

2-Hydroxyestradol 2-methyl ether, 2-Methoxyestradiol- 17β, Panzem

Melting Point

188-190°C

Solubility

Soluble in DMSO or ethanol.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

M1678 MSDS PDF

Info Sheet

M1678 Info Sheet PDF

References

Yuan W, Yu Y, Li J, et al. Estrogen metabolite 2-methoxyestradiol prevents hypertension in deoxycorticosterone acetate-salt rats. Cardiovasc Drugs Ther. 2013 Feb;27(1):17-22. PMID: 23229845.

Salama SA, Diaz-Arrastia CR, Kilic GS, et al. 2-Methoxyestradiol causes functional repression of transforming growth factor β3 signaling by ameliorating Smad and non-Smad signaling pathways in immortalized uterine fibroid cells. Fertil Steril. 2012 Jul;98(1):178-84. PMID: 22579131.

Du B, Wang SY, Shi XF, et al. The effect of 2-methoxyestradiol liposome on growth inhibition, angiogenesis and expression of VEGF and Ki67 in mice bearing H22 hepatocellular carcinoma. Tumori. 2011 Sep-Oct;97(5):660-5. PMID: 22158500.

Garcia GE, Wisniewski HG, Lucia MS, et al. 2-Methoxyestradiol inhibits prostate tumor development in transgenic adenocarcinoma of mouse prostate: role of tumor necrosis factor-alpha-stimulated gene 6. Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):980-8. PMID: 16467113.

Lakhani NJ, Sarkar MA, Venitz J, et al. 2-Methoxyestradiol, a promising anticancer agent. Pharmacotherapy. 2003 Feb;23(2):165-72. PMID: 12587805.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E7657

    Etoposide

    Podophyllotoxin derivative; topoisomerase II in...

    ≥98%
  • D1644

    Deltorphin I

    Opioid peptide; δOR agonist.

    ≥98%
  • L5822

    Lofexidine Hydrochloride

    α2-adrenergic agonist.

    ≥98%
  • C7997

    C-Type Natriuretic Peptide (1-22), human

    Endogenous cardiomodulatory peptide; NPR-B agon...

    ≥95%
  • E4902

    Emamectin B1 Benzoate

    Semi-synthetic avermectin; GABA potentiator.

    ≥80%
  • C179602

    CEP-28122

    ALK inhibitor.

    ≥98%
  • A3212

    3′-Azido-3′-deoxythymidine

    Nucleoside (thymidine) analog; DNA chain termin...

    ≥98%
  • R2816

    Recombinant HIV-2 gp36

    Recombinant HIV-1 glycoprotein antigen fragment...

    ≥95%
  • B242042

    BGB-283

    Dual RAF/EGFR inhibitor.

    ≥98%
  • P2816

    S-(N-3-Phenylpropylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate.

    ≥98%
  • A5061

    Ampalex

    Benzylpiperidine; AMPA potentiator.

    ≥98%
  • Z5653

    Zonisamide

    Sulfonamide; carbonic anhydrase inhibitor, volt...

    ≥96%
  • B1992

    Bexarotene

    RXR agonist.

    ≥98%
  • K040009

    KB-0742 dihydrochloride

    CDK9 inhibitor.

    ≥99%
  • N5605

    Nobiletin

    Polymethoxylated flavone found in citrus fruits...

    ≥97%
  • F4503

    Flavokawain B

    Chalcone kavalactone that suppresses inflammati...

    ≥97%
  • K6276

    (E)-KPT-330

    CRM1-selective inhibitor of nuclear export.

    ≥99%
  • E622698

    Eprosartan Mesylate

    Nonpeptide angiotensin II receptor antagonist

    ≥99%
  • E7329

    Ethoxyquin

    Quinoline, food preservative; HSP90 inhibitor.<...

    ≥90%
  • I7556

    1-Isothiocyanato-7-(methylsulfonyl)-heptane

    ITC, erysolin analog.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only