Description
This compound is a derivative of cephalomannine, found in species of Taxus. Like other taxanes, this compound may inhibit DNA polymerase and microtubule depolymerization, exhibiting anticancer activity.
Product Unit Size | Cost | Quantity | Stock |
---|
This compound is a derivative of cephalomannine, found in species of Taxus. Like other taxanes, this compound may inhibit DNA polymerase and microtubule depolymerization, exhibiting anticancer activity.
Cas No. | 150547-36-7 |
---|---|
Purity | ≥95% |
Formula | C45H53NO14 |
Formula Wt. | 831.9 |
IUPAC Name | [(1S,2S,3R,4S,7R,9R,10S,12R,15S)-4,12-diacetyloxy-1,9-dihydroxy-15-[(2R,3S)-2-hydroxy-3-[[(E)-2-methylbut-2-enoyl]amino]-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate |
Appearance | White to off white powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Li Y, Qin F, Wang SM, et al. Chemical studies on Taxus canadensis. Chem Biodivers. 2013 Oct;10(10):1729-53. PMID: 24130020.
Oshige M, Takenouchi M, Kato Y, et al. Taxol derivatives are selective inhibitors of DNA polymerase alpha. Bioorg Med Chem. 2004 May 15;12(10):2597-601. PMID: 15110841.
Pandey RC, Yankov LK, Poulev A, et al. Synthesis and separation of potential anticancer active dihalocephalomannine diastereomers from extracts of Taxus yunnanensis. J Nat Prod. 1998 Jan;61(1):57-63. PMID: 9461653.
Dihydrofolate reductase inhibitor.
Triterpene sapogenin found in species of Panax;...
PKA substrate.
HPGDS inhibitor.
Fluoroquinolone; bacterial DNA gyrase inhibitor...
Triazolopyrazine; c-MET inhibitor.
Tropane alkaloid found in Solanaceae plants; M1...
Found in plants in Astragalus, Allium, and Bras...
Coumarin; VKORC1 inhibitor.
Flavonoid found in various plant sources; GABA-...
14α-demethylase inhibitor.
Alkaloid found in Galanthus, Narcissus, Leucoju...
Alkaloid found in species of Loranthus, Calia, ...
α-glucosidase inhibitor.
R,R enantiomer of formoterol; β2-adrenergic an...
Modifies microvascular function
SIRT1/2 inhibitor, indirect p53 activator.
Phthalide; PPARγ agonist, IMPDH inhibitor, mic...
MEK1/2 and Raf inhibitor.
Antibiotic