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Atrial natriuretic peptide (ANP) is a cardiomodulatory peptide that binds the natriuretic peptide receptor type A (NPR-A), increasing levels of cGMP and activating cGMP-dependent kinases. ANP exhibits vasodilatory/hypotensive, diuretic, and natriuretic activities, increasing perfusion and decreasing blood pressure in several models. ANP may also exhibit anticancer benefit, targeting the Ras-MEK-ERK signaling pathway.
| Purity | ≥95% |
|---|---|
| Formula | C49H84N20O15S |
| Formula Wt. | 1225.40 |
| Synonym | Atrial natriuretic peptide, ANP |
| Solubility | Soluble in water. |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet |
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Vesely DL. New anticancer agents: hormones made within the heart. Anticancer Res. 2012 Jul;32(7):2515-21. PMID: 22753708.
Woodard GE, Rosado JA. Natriuretic peptides in vascular physiology and pathology. Int Rev Cell Mol Biol. 2008;268:59-93. PMID: 18703404.
