LKT Labs

Biochemicals for Life Science Research

Abamectin

Abamectin

Product ID A0501
Cas No. 71751-41-2
Purity ≥70%
Product Unit SizeCostQuantityStock
1 g $79.10 In stock
5 g $268.20 In stock
25 g $826.90 In stock
Bulk Quote

Quicklinks

Description

Abamectin is a macrocyclic lactone avermectin, produced from the soil organism streptomyes avermitilis, that exhibits antibiotic and anti-fertility activities. Abamectin inhibits F0F1-ATPase and the adenine nucleotide translocator (ANT), preventing mitochondrial respiration and acting as an anti-parasitic/anti-helminthic. Additionally, abamectin decreases sperm count and motility and increases seminiferous tubule damage in male rats. This compound also inhibits GABA receptors in some models; other avermectins increase GABA release, indirectly stimulating activity of GABA receptors.

Product Info

Cas No.

71751-41-2
Purity

≥70%
Formula

C48H72O14(B1a) C47H70O14(B1b)
Chemical Name

Avermectin B(sub 1)
Synonym

Avermectin B1, 5-O-demethyl-25-de(91-methylpropyl)-25- (1-methylethyl)avermectin A1a (4:1)
Melting Point

150-155°C
Solubility

Soluble in methanol, acetone, isopropanol or toluene.
Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

A0501 MSDS PDF
Info Sheet

A0501 Info Sheet PDF

References

Castanha Zanoli JC, Maioli MA, Medeiros HC, et al. Abamectin affects the bioenergetics of liver mitochondria: A potential mechanism of hepatotoxicity. Toxicol In Vitro. 2012 Feb;26(1):51-6. PMID: 22024101.

Celik-Ozenci C, Tasatargil A, Tekcan M, et al. Effects of abamectin exposure on male fertility in rats: potential role of oxidative stress-mediated poly(ADP-ribose) polymerase (PARP) activation. Regul Toxicol Pharmacol. 2011 Dec;61(3):310-7. PMID: 21945325.

Holden-Dye L, Walker RJ. Avermectin and avermectin derivatives are antagonists at the 4-aminobutyric acid (GABA) receptor on the somatic muscle cells of Ascaris; is this the site of anthelmintic action? Parasitology. 1990 Oct;101 Pt 2:265-71. PMID: 2175874.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G0044

    Galantide

    Peptide; galanin antagonist.

    ≥95%
  • M1622

    Mefenamic Acid

    NSAID; GABA-A potentiator, COX-1/2 inhibitor.

    ≥98%
  • L283080

    LHC-165

    TLR7 agonist

    ≥99%
  • S0244

    Salsalate

    Salicylic acid prodrug, NSAID; weak COX-1/2 inh...

    ≥95%
  • T9968

    Tyrphostin A25

    SK K+ channel blocker, EGFR inhibitor.

    ≥98%
  • C5655

    α-Conotoxin GI

    Peptide toxin found in Conus snails; nAChR inhi...

    ≥95%
  • D5610

    Docosahexaenoic Acid (all cis-4,7,10,13,16,19)

    Essential fatty acid found in fish oil, involve...

    ≥98%
  • P1760

    Peptide T

    Peptide fragment of HIV-1 gp120.

    ≥98%
  • D3330

    Dihydrotanshinone

    Found in Salvia; fatty acid synthase and AChE i...

    ≥90%
  • B1979

    Betulinic Acid

    Pentacyclic triterpene.

    ≥99%
  • V3278

    Vitamin E Acetate

    Vitamin E analog, antioxidant.

    ≥98%
  • M1669

    6-Mercaptopurine Monohydrate

    Thiopurine antimetabolite; PRPP amidotransferas...

    ≥98%
  • T1854

    Tenofovir Monohydrate

    Nucleotide analog; RT inhibitor.

    ≥98%
  • Y1000

    Y27632 Dihydrochloride

    ROCK inhibitor.  
    ≥99%
  • L2540

    LGK-974

    PORCN inhibitor.

    ≥98%
  • T564092

    γ-Tocopherol

    Vitamin E component

    ≥98%
  • W0269

    (±)-Warfarin

    Coumarin; VKORC1 inhibitor.

    ≥98%
  • A9435

    Axitinib

    VEGFR inhibitor.

    ≥98%
  • P2502

    Phenethyl Glucosinolate Potassium

    Found in cruciferous vegetables.

    ≥97%
  • L0251

    Laminin Peptide CDPGYIGSR

    Laminin-derived nonapeptide.

    ≥98%