LKT Labs

Biochemicals for Life Science Research

Abamectin

Abamectin

Product ID A0501
Cas No. 71751-41-2
Purity ≥70%
Product Unit SizeCostQuantityStock
1 g $79.10 In stock
5 g $268.20 In stock
25 g $826.90 In stock
Bulk Quote

Quicklinks

Description

Abamectin is a macrocyclic lactone avermectin, produced from the soil organism streptomyes avermitilis, that exhibits antibiotic and anti-fertility activities. Abamectin inhibits F0F1-ATPase and the adenine nucleotide translocator (ANT), preventing mitochondrial respiration and acting as an anti-parasitic/anti-helminthic. Additionally, abamectin decreases sperm count and motility and increases seminiferous tubule damage in male rats. This compound also inhibits GABA receptors in some models; other avermectins increase GABA release, indirectly stimulating activity of GABA receptors.

Product Info

Cas No.

71751-41-2
Purity

≥70%
Formula

C48H72O14(B1a) C47H70O14(B1b)
Chemical Name

Avermectin B(sub 1)
Synonym

Avermectin B1, 5-O-demethyl-25-de(91-methylpropyl)-25- (1-methylethyl)avermectin A1a (4:1)
Melting Point

150-155°C
Solubility

Soluble in methanol, acetone, isopropanol or toluene.
Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

A0501 MSDS PDF
Info Sheet

A0501 Info Sheet PDF

References

Castanha Zanoli JC, Maioli MA, Medeiros HC, et al. Abamectin affects the bioenergetics of liver mitochondria: A potential mechanism of hepatotoxicity. Toxicol In Vitro. 2012 Feb;26(1):51-6. PMID: 22024101.

Celik-Ozenci C, Tasatargil A, Tekcan M, et al. Effects of abamectin exposure on male fertility in rats: potential role of oxidative stress-mediated poly(ADP-ribose) polymerase (PARP) activation. Regul Toxicol Pharmacol. 2011 Dec;61(3):310-7. PMID: 21945325.

Holden-Dye L, Walker RJ. Avermectin and avermectin derivatives are antagonists at the 4-aminobutyric acid (GABA) receptor on the somatic muscle cells of Ascaris; is this the site of anthelmintic action? Parasitology. 1990 Oct;101 Pt 2:265-71. PMID: 2175874.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L8377

    Luteolin

    Flavonoid found in various plant sources; DAT a...

    ≥95%
  • C0824

    CCG1423

    Serum response factor inhibitor and MRTF-A bind...

    ≥98%
  • W0270

    (±)-Warfarin Sodium Clathrate

    Coumarin; VKORC1 inhibitor.

    ≥98%
  • T3033

    Thienyldodecyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥98%
  • A1333

    Adipokinetic Hormone II from Schistocera gregaria

    Neuropeptide found in Schistocera gregaria.

    ≥95%
  • C2942

    Mechlorethamine Hydrochloride

    Nitrogen mustard, DNA alkylator.

    ≥98%
  • S0244

    Salsalate

    Salicylic acid prodrug, NSAID; weak COX-1/2 inh...

    ≥95%
  • M1650

    Melanotan II

    Synthetis peptide, melanocortin analog; MCR ago...

    ≥98%
  • B5874

    Bosutinib

    Src and Abl inhibitor.

    ≥98%
  • P2502

    Phenethyl Glucosinolate Potassium

    Found in cruciferous vegetables.

    ≥97%
  • T1030

    N-Des-2-methylpropan-2-ol Docetaxel

    N-Des-2-methylpropan-2-ol Docetaxel is an impur...

    ≥90%
  • C1613

    Cediranib

    VEGFR inhibitor.

    ≥98%
  • S3353

    Sinomenine Hydrochloride

    Alkaloid found in Sinomenium; acid-sensing ion ...

    ≥98%
  • K0031

    Kahweol Acetate

    Diterpene found in coffee beans.

    ≥98%
  • R3374

    Risedronic Acid

    Bisphosphonate; inhibits transfer of farnesyl p...

    ≥97%
  • S760004

    Stachybotrylactam

    Spirodihydrobenzofuranlactam

    ≥98%
  • H9716

    (E,Z)-4-Hydroxytamoxifen

    Selective estrogen receptor modulator.

    ≥97%
  • D3431

    3,4-Dihydroxyphenyl Ethanol

    Polyphenol found in olive oil, antioxidant.

    ≥95%
  • M1644

    Meloxicam

    NSAID; COX-2 inhibitor.

    ≥98%
  • T3031

    Thienylbutyl Isothiocyanate

    ITC.

    ≥96%