LKT Labs

Biochemicals for Life Science Research

Acalabrutinib

Product ID A081014
Cas No. 1420477-60-6
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $110.40 In stock
25 mg $292.10 In stock
100 mg $843.60 In stock
Bulk Quote

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Description

Acalabrutinib is an inhibitor of Bruton’s tyrosine kinase (BTK). It showed increased selectivity compared with first generation BTK inhibitors such as ibrutinib while offering similar antitumor efficacy in mouse models of chronic lymphocytic leukemia. It has been approved for the treatment of patients with relapsed mantle cell lymphoma(MCL), a unique type of non-Hodgkin lymphoma characterized by the overexpression of cyclin D1. It is currently being investigated as a front line treatment for MCL.

Product Info

Cas No.

1420477-60-6
Purity

≥99%
Formula

C26H23N7O2
Formula Wt.

465.52
IUPAC Name

4-{8-Amino-3-[(2S)-1-(2-butynoyl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl}-N-(2-pyridinyl)benzamide
Synonym

ACP-196

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A081014 MSDS PDF
Info Sheet

A081014 Info Sheet PDF

References

Herman S., Montraveta A., et al. The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia. Clin Cancer Res. 23(11):2831-41 (2016). PMID:27903679.

Witzig T., Inwards D. Acalabrutinib for mantle cell lymphoma. Blood. 133(24):2570-74 (2019). PMID: 30967367.

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