LKT Labs

Biochemicals for Life Science Research

Acalabrutinib

Acalabrutinib

Product ID A081014
Cas No. 1420477-60-6
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $115.90 In stock
25 mg $306.70 In stock
100 mg $885.80 In stock
Bulk Quote

Quicklinks

Description

Acalabrutinib is an inhibitor of Bruton’s tyrosine kinase (BTK). It showed increased selectivity compared with first generation BTK inhibitors such as ibrutinib while offering similar antitumor efficacy in mouse models of chronic lymphocytic leukemia. It has been approved for the treatment of patients with relapsed mantle cell lymphoma(MCL), a unique type of non-Hodgkin lymphoma characterized by the overexpression of cyclin D1. It is currently being investigated as a front line treatment for MCL.

Product Info

Cas No.

1420477-60-6
Purity

≥99%
Formula

C26H23N7O2
Formula Wt.

465.52
IUPAC Name

4-{8-Amino-3-[(2S)-1-(2-butynoyl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl}-N-(2-pyridinyl)benzamide
Synonym

ACP-196

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A081014 MSDS PDF
Info Sheet

A081014 Info Sheet PDF

References

Herman S., Montraveta A., et al. The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia. Clin Cancer Res. 23(11):2831-41 (2016). PMID:27903679.

Witzig T., Inwards D. Acalabrutinib for mantle cell lymphoma. Blood. 133(24):2570-74 (2019). PMID: 30967367.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D3331

    α,β-Dihydroresveratrol

    Polyphenol found in various plant sources, resv...

    ≥99%
  • T1776

    D-Tetrahydropalmatine

    Alkaloid found in Corydalis; D1 antagonist, org...

    ≥99%
  • B8144

    Bulleyaconitine A

    Found in Aconitum bulleyanum; voltage-gated Na+...

    ≥95%
  • S6018

    Spectinomycin Dihydrochloride Pentahydrate

    Aminocyclitol; protein synthesis inhibitor. &nb...
    ≥603 µg/mg (potency)
  • A8644

    AVL-292

    BTK inhibitor.

    ≥98%
  • P9668

    Pyrantel Pamoate

    Mixture of pyrantel, a thiophene, and pamoic ac...

    ≥98%
  • C3374

    Cisplatin

    Pt-based DNA cross-linker.

    ≥99%
  • P6858

    Procarbazine Hydrochloride

    Hydrazine derivative, DNA alkylator; MAO inhibi...

    ≥97%
  • Y0052

    Yangonin

    Dienolide kavalactone originally found in Piper...

    ≥98%
  • E537335

    Enniatin B1

    Mycotoxin contaminant found in cereal grains.

    ≥98%
  • R0349

    Ramosetron

    5-HT3 antagonist.

    ≥99%
  • A0970

    Adrenocorticotropic Hormone (18-39), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • G3458

    Ginsenoside Rg1

    Triterpene saponin found in species of Panax.

    ≥98%
  • S8098

    SU-1498

    Tyrphostin; VEGFR inhibitor.

    ≥99%
  • I058584

    Ibotenic Acid

    Analog of glutamate

    ≥98%
  • T7132

    Triacetyl Resveratrol

    Resveratrol prodrug; potential SIRT1 activator....

    ≥99%
  • A0802

    Acarbose

    α-glucosidase inhibitor.

    ≥98%
  • F1670

    Ferulic Acid Methyl Ester

    Hydroxycinnamic aicd, verbascoside metabolite, ...

    ≥98%
  • F4584

    Fluphenazine Hydrochloride

    Piperazine; FIASMA, D2 antagonist, hERG K+ chan...

    ≥97%
  • O486181

    Omeprazole Related Compound B

    Impurity of omeprazole

    ≥99%