LKT Labs

Biochemicals for Life Science Research

Acalabrutinib

Acalabrutinib

Product ID A081014
Cas No. 1420477-60-6
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $116.00 In stock
25 mg $307.00 In stock
100 mg $886.00 In stock
Bulk Quote

Quicklinks

Description

Acalabrutinib is an inhibitor of Bruton’s tyrosine kinase (BTK). It showed increased selectivity compared with first generation BTK inhibitors such as ibrutinib while offering similar antitumor efficacy in mouse models of chronic lymphocytic leukemia. It has been approved for the treatment of patients with relapsed mantle cell lymphoma(MCL), a unique type of non-Hodgkin lymphoma characterized by the overexpression of cyclin D1. It is currently being investigated as a front line treatment for MCL.

Product Info

Cas No.

1420477-60-6
Purity

≥99%
Formula

C26H23N7O2
Formula Wt.

465.52
IUPAC Name

4-{8-Amino-3-[(2S)-1-(2-butynoyl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl}-N-(2-pyridinyl)benzamide
Synonym

ACP-196

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A081014 MSDS PDF
Info Sheet

A081014 Info Sheet PDF

References

Herman S., Montraveta A., et al. The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia. Clin Cancer Res. 23(11):2831-41 (2016). PMID:27903679.

Witzig T., Inwards D. Acalabrutinib for mantle cell lymphoma. Blood. 133(24):2570-74 (2019). PMID: 30967367.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C864760

    CVT-313

    Selective CDK2 inhibitor.

    ≥98%
  • M4652

    MLN8237

    AurKA inhibitor.

    ≥98%
  • T0249

    Tamibarotene

    RARα/β agonist.

    ≥98%
  • S1059

    Scopolamine Hydrobromide Trihydrate

    Tropane alkaloid found in Solanaceae plants; M1...

    ≥98%
  • M0126

    Magainin 2

    Antimicrobial peptide found in frogs, induces p...

    ≥95%
  • T2833

    1-Thio-β-D-glucose Tetraacetate

    Imaging agent; Maillard reaction inhibitor.

    ≥98%
  • O4549

    Olmesartan Medoxomil

    AT1 inhibitor.

    ≥98%
  • F4881

    Flumequine Sodium

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • V0369

    Varenicline Tartrate

    α7 and β4 nAChR agonist, α4β2 and α6β2 nA...

    ≥99%
  • I7259

    Isoproterenol Hydrochloride

    β-adrenergic agonist.

    ≥98%
  • B5044

    BML-277

    Arylbenzimidazole; CHK2 inhibitor.

    ≥98%
  • Z2268

    Z-FR-AMC

    Protease substrate.

    ≥95%
  • W5726

    Wogonin

    Flavonoid found in Scutellaria; CDK9 inhibitor....

    ≥98%
  • E7309

    Esculetin

    Coumarin lactone found in chicory and other pla...

    ≥99%
  • F334451

    Filipin Complex

    A probe for cholesterol in biological membranes...

    ≥97%
  • E5569

    Enramycin B

    Polypeptide; peptidoglycan inhibitor.

    ≥83%
  • O4533

    Oligomycin

    Mixture of oligomycins A, B, C; oxidative phosp...

    ≥97%
  • B3275

    Bis(3,5-dibromosalicyl) Succinate

    Aspirin analog; hemoglobin chain cross-linker.<...

    ≥95%
  • T1002

    2-Debenzoyl Paclitaxel-2-(2-Methyl-2-Butenoate)

    Synthesis intermediate

    ≥95%
  • A0401

    Abacavir

    Nucleoside (guanosine) analog; RT, guanylyl cyc...

    ≥98%