LKT Labs

Biochemicals for Life Science Research

Acalabrutinib

Acalabrutinib

Product ID A081014
Cas No. 1420477-60-6
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $116.00 In stock
25 mg $307.00 In stock
100 mg $886.00 In stock
Bulk Quote

Quicklinks

Description

Acalabrutinib is an inhibitor of Bruton’s tyrosine kinase (BTK). It showed increased selectivity compared with first generation BTK inhibitors such as ibrutinib while offering similar antitumor efficacy in mouse models of chronic lymphocytic leukemia. It has been approved for the treatment of patients with relapsed mantle cell lymphoma(MCL), a unique type of non-Hodgkin lymphoma characterized by the overexpression of cyclin D1. It is currently being investigated as a front line treatment for MCL.

Product Info

Cas No.

1420477-60-6
Purity

≥99%
Formula

C26H23N7O2
Formula Wt.

465.52
IUPAC Name

4-{8-Amino-3-[(2S)-1-(2-butynoyl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl}-N-(2-pyridinyl)benzamide
Synonym

ACP-196

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A081014 MSDS PDF
Info Sheet

A081014 Info Sheet PDF

References

Herman S., Montraveta A., et al. The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia. Clin Cancer Res. 23(11):2831-41 (2016). PMID:27903679.

Witzig T., Inwards D. Acalabrutinib for mantle cell lymphoma. Blood. 133(24):2570-74 (2019). PMID: 30967367.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A9803

    Azathioprine

    Purine nucleotide analog, mercaptiopurine prodr...

    ≥98%
  • P0392

    Paxilline

    Neuroactive mycotoxin produced by Penicillum an...

    ≥98%
  • B1603

    Beauvericin

    Cyclic hexadepsipeptide mycotoxin produced by C...

    ≥95%
  • G4781

    Glucoraphanin Potassium

    Glucosinolate found in cruciferous vegetables.<...

    ≥98%
  • T1854

    Tenofovir Monohydrate

    Nucleotide analog; RT inhibitor.

    ≥98%
  • L0349

    Lamotrigine

    R-type Ca2+ and voltage-gated Na+ channel block...

    ≥98%
  • B3300

    BI-6727

    PLK1 inhibitor.

    ≥99%
  • P4403

    Plasminogen Activator Inhibitor 1

    Endogenous peptide, produced by activation of P...

    ≥95%
  • V3455

    Vinpocetine

    Targets nuclear factor kappa B activation.

    ≥98%
  • O9201

    Oxaliplatin

    Pt-based DNA cross-linker.

    ≥98%
  • A4926

    AMG-458

    c-MET inhibitor.

    ≥98%
  • M0273

    Mastoparan 8

    Antimicrobial peptide found in bee and wasp ven...

    ≥95%
  • A121008

    Adagrasib

    KRAS inhibitor

    ≥99%
  • N0262

    Naphazoline Hydrochloride

    α1-adrenergic agonist.

    ≥97%
  • I530280

    INH1

    Hec1/Nek2 mitotic pathway inhibitor

    ≥98%
  • T1678

    D,L-Tetrahydropalmatine

    Alkaloid found in Corydalis and Stephania; D1/2...

    ≥98%
  • D3219

    Diflubenzuron

    Benzoylurea, insect growth regulator; chitin sy...

    ≥95%
  • A980005

    AZ-5104

    Inhibitor of EGFR.

    ≥98%
  • C0377

    Catharanthine Sulfate

    Alkaloid found in Catharanthus, precursor in sy...

    ≥98%
  • C179603

    CEP-37440 Hydrochloride

    Inhibitor of FAK and ALK.

    ≥99%