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Adapalene

Adapalene

Product ID A1202
Cas No. 106685-40-9
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $214.00 In stock
250 mg $377.70 In stock
1 g $956.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Adapalene is a derivative of tretinoin that is clinically used to treat acne and pityriasis versicolor. This synthetic retinoid exhibits anti-inflammatory activity, decreasing expression of Ki67, α2-integrin, α6-integrin, toll-like receptor 2 (TLR2), IL-8, and β-defensin in ex vivo models. Like other retinoids, adapalene also activates retinoic acid receptors RARα/β/γ across several models.

Product Info

Cas No.

106685-40-9

Purity

≥98%

Formula

C28H28O3

Formula Wt.

412.52

IUPAC Name

6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid

Melting Point

319-322C

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A1202 MSDS PDF

Info Sheet

A1202 Info Sheet PDF

References

Tirado-Sánchez A, Espíndola YS, Ponce-Olivera RM, et al. Efficacy and safety of adapalene gel 0.1% and 0.3% and tretinoin gel 0.05% for acne vulgaris: results of a single-center, randomized, double-blinded, placebo-controlled clinical trial on Mexican patients (skin type III-IV). J Cosmet Dermatol. 2013 Jun;12(2):103-7. PMID: 23725303.

Shi TW, Ren XK, Yu HX, et al. Roles of adapalene in the treatment of pityriasis versicolor. Dermatology. 2012;224(2):184-8. PMID: 22572567.

Zuliani T, Khammari A, Chaussy H, et al. Ex vivo demonstration of a synergistic effect of Adapalene and benzoyl peroxide on inflammatory acne lesions. Exp Dermatol. 2011 Oct;20(10):850-3. PMID: 21793939.

Michel S, Jomard A, Démarchez M. Pharmacology of adapalene. Br J Dermatol. 1998 Oct;139 Suppl 52:3-7. PMID: 9990413.

Bernard BA. Adapalene, a new chemical entity with retinoid activity. Skin Pharmacol. 1993;6 Suppl 1:61-9. PMID: 8142113.

Custom Order

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