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AK-7 is an inhibitor of sirtuin 2 (SIRT2); sirtuins are considered class III histone deacetylases (HDACs). AK-7 exhibits neuroprotective activity, decreasing brain atrophy and improving motor function and survival in animal models of Huntington’s disease.
| Cas No. | 420831-40-9 |
|---|---|
| Purity | ≥98% |
| Formula | C19H21BrN2O3S |
| Formula Wt. | 437.35 |
| IUPAC Name | 3-(azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide |
| Synonym | AK7 |
| Solubility | 100mM in DMSO |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Chopra V, Quinti L, Kim J, et al. The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models. Cell Rep. 2012 Dec 27;2(6):1492-7. PMID: 23200855.