LKT Labs

Biochemicals for Life Science Research

Alternariol

Alternariol

Product ID A4675
Cas No. 641-38-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $184.00 In stock
5 mg $681.00 Please Inquire
Bulk Quote

Quicklinks

Description

Alternariol is a mycotoxin initially produced by species of Alternaria. Alternariol produces a weak estrogenic response in vitro and increases production of estradiol and progesterone. Alternariol is also cytotoxic; in macrophages, it increases DNA base oxidations and strand breaks. Also in macrophages, alternariol increases levels of cyclin B1 and p-cdc2, inducing G2/M phase cell cycle arrest. This compound also increases expression of DNA polymerase β through alterations in PKA-CREB signaling. Additionally, alternariol inhibits topoisomerase I and II, preventing DNA relaxation and cleavage.

Warning: Highly toxic. May be mutagenic.

Product Info

Cas No.

641-38-3
Purity

≥98%
Formula

C14H10O5
Formula Wt.

258.23
Chemical Name

3,4,4'-Trihydroxy-6'-methyl-2-biphenylcarboxylic acid, gamma lactone
IUPAC Name

3,7,9-trihydroxy-1-methylbenzo[c]chromen-6-one
Solubility

Soluble in DMSO, ethanol and methanol,
Appearance

Light blue-green powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

A4675 MSDS PDF
Info Sheet

A4675 Info Sheet PDF

References

Frizzell C, Ndossi D, Kalayou S, et al. An in vitro investigation of endocrine disrupting effects of the mycotoxin alternariol. Toxicol Appl Pharmacol. 2013 Aug 15;271(1):64-71. PMID: 23665424.

Solhaug A, Holme JA, Haglund K, et al. Alternariol induces abnormal nuclear morphology and cell cycle arrest in murine RAW 264.7 macrophages. Toxicol Lett. 2013 May 10;219(1):8-17. PMID: 23454835.

Broggi L, Reynoso C, Resnik S, et al. Occurrence of alternariol and alternariol monomethyl ether in beverages from the Entre Rios Province market, Argentina. Mycotoxin Res. 2013 Feb;29(1):17-22. PMID: 23334721.

Scott PM, Zhao W, Feng S, et al. Alternaria toxins alternariol and alternariol monomethyl ether in grain foods in Canada. Mycotoxin Res. 2012 Nov;28(4):261-6. PMID: 23087499.

Solhaug A, Vines LL, Ivanova L, et al. Mechanisms involved in alternariol-induced cell cycle arrest. Mutat Res. 2012 Oct-Nov;738-739:1-11. PMID: 23031795.

Zhao J, Liu K, Lu J, et al. Alternariol induces DNA polymerase β expression through the PKA-CREB signaling pathway. Int J Oncol. 2012 Jun;40(6):1923-8. PMID: 22406678.

Fehr M, Pahlke G, Fritz J, et al. Alternariol acts as a topoisomerase poison, preferentially affecting the IIalpha isoform. Mol Nutr Food Res. 2009 Apr;53(4):441-51. PMID: 18727009.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • Z161024

    α-Zearalenol

    Mycotoxin that has structural similarity to est...

    ≥98%
  • E0929

    Echinacoside

    Phenylethanoid glycoside found in Echinacea.

    ≥98%
  • A7669

    A-type Natriuretic Peptide (1-28), rat

    Endogenous cardiomodulatory peptide; NPR-A agon...

    ≥95%
  • B0110

    Baclofen

    GABA derivative; GABA-B agonist.

    ≥98%
  • T2404

    TG101348

    JAK2 inhibitor.

    ≥98%
  • E6825

    Ergosterol

    Sterol cell membrane component found in yeast a...

    ≥96%
  • E7758

    Etomidate

    GABA-A agonist.

    ≥99%
  • O4556

    Olomoucine

    Purine derivative; CDK inhibitor.

    ≥98%
  • M1649

    Melanoma-associated Antigen Peptide 1 (27-35), human

    Melanoma-associated antigen.

    ≥95%
  • C1624

    Cefuroxime Sodium

    β-lactam; penicillin binding protein inhibitor...

    ≥98%
  • V9201

    VX-11e

    ERK2 inhibitor, potential AurKA, GSK3, CDK2, FL...

    ≥98%
  • B8278

    Butoconazole Nitrate

    Imidazole; 14-α demethylase inhibitor.

    ≥98%
  • I0801

    IC261

    Casein kinase 1 inhibitor.

    ≥98%
  • P8370

    Purmorphamine

    Hedgehog and Smo agonist.

    ≥98%
  • P2997

    Phytic Acid, 40-50 wt% aqueous solution

    Saturated cyclic acid used to store phosphorus ...

    ≥40%
  • G3461

    Ginsenoside F2

    Triterpene saponin found in species of Panax.

    ≥98%
  • C4758

    Closantel Sodium

    Protonophore; chitinase OvCHT1 inhibitor.

    ≥98%
  • O456505

    Olmutinib

    EGFR inhibitor.

    ≥98%
  • E4785

    Elvitegravir

    Integrase inhibitor.

    ≥98%
  • P1770

    Perillyl Alcohol

    Terpene found in various plant and fruit source...

    ≥95%