LKT Labs

Biochemicals for Life Science Research

Alternariol

Alternariol

Product ID A4675
Cas No. 641-38-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $184.00 In stock
5 mg $681.30 Please Inquire
Bulk Quote

Quicklinks

Description

Alternariol is a mycotoxin initially produced by species of Alternaria. Alternariol produces a weak estrogenic response in vitro and increases production of estradiol and progesterone. Alternariol is also cytotoxic; in macrophages, it increases DNA base oxidations and strand breaks. Also in macrophages, alternariol increases levels of cyclin B1 and p-cdc2, inducing G2/M phase cell cycle arrest. This compound also increases expression of DNA polymerase β through alterations in PKA-CREB signaling. Additionally, alternariol inhibits topoisomerase I and II, preventing DNA relaxation and cleavage.

Warning: Highly toxic. May be mutagenic.

Product Info

Cas No.

641-38-3
Purity

≥98%
Formula

C14H10O5
Formula Wt.

258.23
Chemical Name

3,4,4'-Trihydroxy-6'-methyl-2-biphenylcarboxylic acid, gamma lactone
IUPAC Name

3,7,9-trihydroxy-1-methylbenzo[c]chromen-6-one
Solubility

Soluble in DMSO, ethanol and methanol,
Appearance

Light blue-green powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

A4675 MSDS PDF
Info Sheet

A4675 Info Sheet PDF

References

Frizzell C, Ndossi D, Kalayou S, et al. An in vitro investigation of endocrine disrupting effects of the mycotoxin alternariol. Toxicol Appl Pharmacol. 2013 Aug 15;271(1):64-71. PMID: 23665424.

Solhaug A, Holme JA, Haglund K, et al. Alternariol induces abnormal nuclear morphology and cell cycle arrest in murine RAW 264.7 macrophages. Toxicol Lett. 2013 May 10;219(1):8-17. PMID: 23454835.

Broggi L, Reynoso C, Resnik S, et al. Occurrence of alternariol and alternariol monomethyl ether in beverages from the Entre Rios Province market, Argentina. Mycotoxin Res. 2013 Feb;29(1):17-22. PMID: 23334721.

Scott PM, Zhao W, Feng S, et al. Alternaria toxins alternariol and alternariol monomethyl ether in grain foods in Canada. Mycotoxin Res. 2012 Nov;28(4):261-6. PMID: 23087499.

Solhaug A, Vines LL, Ivanova L, et al. Mechanisms involved in alternariol-induced cell cycle arrest. Mutat Res. 2012 Oct-Nov;738-739:1-11. PMID: 23031795.

Zhao J, Liu K, Lu J, et al. Alternariol induces DNA polymerase β expression through the PKA-CREB signaling pathway. Int J Oncol. 2012 Jun;40(6):1923-8. PMID: 22406678.

Fehr M, Pahlke G, Fritz J, et al. Alternariol acts as a topoisomerase poison, preferentially affecting the IIalpha isoform. Mol Nutr Food Res. 2009 Apr;53(4):441-51. PMID: 18727009.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E846184

    Everolimus EP Impurity B

    Everolimus impurity

    ≥96% (mix of E/Z)
  • A0958

    Aconitine

    Toxin found in Aconitum; voltage-gated Na+ chan...

    ≥95%
  • D0005

    Dabrafenib Mesylate

    B-Raf and c-Raf inhibitor.

    ≥98%
  • E543721

    Ensartinib

    A third-generation ALK inhibitor.

    ≥98%
  • K1653

    Kendomycin

    Macrolide; ET antagonist, proteasome inhibitor....

    ≥98%
  • D5869

    Doripenem Hydrate

    β-lactam carbapenem; penicillin binding protei...

    ≥99%
  • A4000

    AK-1

    SIRT2 inhibitor.

    ≥99%
  • U8000

    U-74389G

    Antioxidant shown to improve renal function.

    ≥95%
  • T1654

    Tenoxicam

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • A7460

    Asparaginase

    Catalyzes hydrolysis of asparagine.

    ≥98%
  • G733400

    GSK-2578215A

    Selective inhibitor of LRRK2.

    ≥98%
  • B4402

    Blasticidin S Hydrochloride

    Protein translation inhibitor.

    ≥98%
  • E8419

    Everolimus

    mTORC1 inhibitor.

    ≥98%
  • B3209

    Bicalutamide

    AR antagonist.

    ≥98%
  • B5648

    Bombesin

    GRP analog, found in Bombina; bombesin and GRP ...

    ≥95%
  • T1004

    Paclitaxel Oxetane Ring-Opened 3-Acetyl 4-Benzoyl Impurity

    Synthesis impurity

    ≥92%
  • N344780

    N-Nitroso Bumetanide

    Bumetanide impurity

    ≥99%
  • K1978

    Ketorolac Tromethamine

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • S1845

    L-(+)-Selenomethionine

    Naturally occurring amino acid found in grains,...

    ≥98%
  • O9398

    Oxymetazoline Hydrochloride

    Imidazoline derivative; α1-adrenergic agonist,...

    ≥98%