LKT Labs

Biochemicals for Life Science Research

Alternariol-9-methyl Ether

Alternariol-9-methyl Ether

Product ID A4678
Cas No. 26894-49-5; 23452-05-3
Purity ≥98%
Product Unit SizeCostQuantityStock
0.1 mg $54.60 In stock
1 mg $330.60 Please Inquire
5 mg $1,277.00 Please Inquire
Bulk Quote

Quicklinks

Description

Alternariol 9-methyl ether (A9ME) is a highly toxic mutagenic phytotoxin initially produced by species of Alternaria. A9ME is present in grain and fruit used for livestock feed and human consumption. A9ME inhibits the electron transport chain, preventing photosynthesis in vitro. Additionally, A9ME may exhibit anticancer potential in a cellular model of colon carcinoma, as it decreases the mitochondrial membrane potential, increasing release of cytochrome c and activating caspases 3 and 9; this results in apoptosis and cell death.

Product Info

Cas No.

26894-49-5; 23452-05-3
Purity

≥98%
Formula

C15H12O5
Formula Wt.

272.25
Chemical Name

6H-Dibenzo(b,d)pyran-6-one, 3,7-dihydroxy-9-methoxy-1-methyl
IUPAC Name

3,7-dihydroxy-9-methoxy-1-methylbenzo[c]chromen-6-one
Synonym

AME; Djalonensone; Alternariol monomethyl ether; Alternariol methyl ether; Alternariol-9-methyl ether
Solubility

Soluble in DMSO, ethanol, methanol
Appearance

Beige Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

A4678 MSDS PDF
Info Sheet

A4678 Info Sheet PDF

References

Demuner AJ, Barbosa LC, Miranda AC, et al. The Fungal Phytotoxin Alternariol 9-Methyl Ether and Some of Its Synthetic Analogues Inhibit the Photosynthetic Electron Transport Chain. J Nat Prod. 2013 Nov 18. [Epub ahead of print]. PMID: 24245962.

Broggi L, Reynoso C, Resnik S, et al. Occurrence of alternariol and alternariol monomethyl ether in beverages from the Entre Rios Province market, Argentina. Mycotoxin Res. 2013 Feb;29(1):17-22. PMID: 23334721.

Scott PM, Zhao W, Feng S, et al. Alternaria toxins alternariol and alternariol monomethyl ether in grain foods in Canada. Mycotoxin Res. 2012 Nov;28(4):261-6. PMID: 23087499.

Bensassi F, Gallerne C, el Dein OS, et al. Mechanism of Alternariol monomethyl ether-induced mitochondrial apoptosis in human colon carcinoma cells. Toxicology. 2011 Dec 18;290(2-3):230-40. PMID: 22001388.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P0932

    PCI-32765

    BTK and IL-2-inducible kinase inhibitor.

    ≥99%
  • C0156

    9-Nitro-20S-camptothecin

    Camptothecin derivative; topoisomerase I inhibi...

    ≥98%
  • D0244

    Dalcetrapib

    Cholesterol ester transfer protein inhibitor.

    ≥98%
  • G1853

    Genipin

    Iridoid glycoside found in Gardinia jasminoides...

    ≥99%
  • V3276

    Vitamin E, Natural

    Antioxidant.

    ≥97%
  • S5722

    Sofosbuvir

    Viral RNA polymerase inhibitor.

    ≥98%
  • V0376

    Vatalanib Dihydrochloride

    VEGFR inhibitor.

    ≥98%
  • A0910

    N-Acetyl-S-(N′-phenylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate, antioxidant.

    ≥98%
  • C0252

    Canertinib Dihydrochloride

    EGFR inhibitor.

    ≥98%
  • A1017

    Aceclofenac

    Diclofenac analog, NSAID; COX-2 inhibitor.

    ≥98%
  • A4803

    Amantadine Sulfate

    Viral M2 proton channel blocker, MAO-A, NET, NM...

    ≥98%
  • N5652

    Nonactin

    Naturally-ocurring neurtral cyclic ionophore, m...

    ≥95%, TLC
  • S4244

    SKLB 610

    VEGFR2, PDGFR, FGFR2 inhibitor.

    ≥98%
  • P0370

    Paromomycin Sulfate

    Aminoglycoside; protein translation inhibitor, ...

    ≥98%
  • A4606

    Albendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥95%
  • T8006

    Tubastatin A Hydrochloride

    HDAC6/10 inhibitor.

    ≥98%
  • A6827

    Argipressin Acetate

    Endogenous peptide, involved in vascular contra...

    ≥95%
  • D1777

    Desmopressin Acetate

    Synthetic peptide, vasopressin derivative; V2 a...

    ≥95%
  • V1769

    Verapamil Hydrochloride

    L-type Ca2+ channel blocker.

    ≥98%
  • L960004

    LY-404187

    Selective positive allosteric modulator of AMPA...

    ≥98%