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Altertoxin 1

Altertoxin 1

Product ID A464768
Cas No. 56258-32-3
Purity ≥97%
Product Unit SizeCostQuantityStock
100 µg $131.30 Please Inquire
1 mg $721.20 In stock
5 mg $3,004.90 In stock
10 mg $5,258.50 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Altertoxin I is a mycotoxin produced by the fungi Alternaria alternata that is found as a contaminant in food an feed, particularly after a long period of storage. Altertoxin I is a metabolite that has been found to reduce the supercoiling activity of DNA gyrase. In addition, Altertoxin I has been evaluated for the ability to inhibit HIV-1 viral replication in A3.01 infected cells and was found to produce nearly complete inhibition.

Product Info

Cas No.

56258-32-3

Purity

≥97%

Formula

C20H16O6

Formula Wt.

352.34

Chemical Name

(12S,12aS,12bR)-4,9,12,12b-tetrahydroxy-2,11,12,12a-tetrahydro-1H-perylene-3,10-dione

IUPAC Name

(1S,12aR,12bS)-1,4,9,12a-Tetrahydroxy-1,2,11,12,12a,12b-hexahydro-3,10-perylenedione

Synonym

(12S,12As,12Br)-4,9,12,12B-Tetrahydroxy-2,11,12,12A-Tetrahydro-1H-Perylene-3,10-Quinone, Altertoxin-I

Solubility

Clear slight pink solution at 10mg/ml of Dichloromethane

Appearance

White to Off-White powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A464768 MSDS PDF

Info Sheet

A464768 Info Sheet PDF

References

Jarolim K, Del Favero G, Ellmer D, et al. Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase. Arch Toxicol. 2017 Apr;91(4):2007-2016. PMID: 27682608.

Jarolim K, Del Favero G, Pahlke G, et al. Activation of the Nrf2-ARE pathway by the Alternaria alternata mycotoxins altertoxin I and II. Arch Toxicol. 2017 Jan;91(1):203-216. PMID: 27178040.

Bashyal BP, Wellensiek BP, Ramakrishnan R, et al. Altertoxins with potent anti-HIV activity from Alternaria tenuissima QUE1Se, a fungal endophyte of Quercus emoryi. Bioorg Med Chem. 2014 Nov 1;22(21):6112-6116. PMID: 25260957.

Pruss S, Fetzner R, Seither K, et al. Role of the Alternaria alternata blue-light receptor LreA (white-collar 1) in spore formation and secondary metabolism. Appl Environ Microbiol. 2014 Apr;80(8):2582-2591. PMID: 24532063.

Stack ME, Prival MJ. Mutagenicity of the Alternaria metabolites altertoxins I, II, and III. Appl Environ Microbiol. 1986 Oct;52(4):718-722. PMID: 3535674.

Custom Order

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