Description
Altretamine is an anticancer chemotherapeutic agent that binds DNA at guanine and cytosine residues, forming DNA adducts. This alkylating agent is also metabolized to formaldehyde. Altretamine is clinically used to treat ovarian cancer.
| Product Unit Size | Cost | Quantity | Stock |
|---|
Altretamine is an anticancer chemotherapeutic agent that binds DNA at guanine and cytosine residues, forming DNA adducts. This alkylating agent is also metabolized to formaldehyde. Altretamine is clinically used to treat ovarian cancer.
| Cas No. | 645-05-6 |
|---|---|
| Purity | ≥98% |
| Formula | C9H18N6 |
| Formula Wt. | 210.28 |
| Chemical Name | N,N,N',N',N'',N''-Hexamethyl-1,3,5-triazine-2,4,6-triamine |
| IUPAC Name | 2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine |
| Synonym | HMM, Hexalen, Hexamethylmelamine |
| Melting Point | 172-174°C |
| Solubility | Practically insoluble in water. Soluble in DMSO. |
| Appearance | White Crystal Powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Chan JK, Loizzi V, Manetta A, et al. Oral altretamine used as salvage therapy in recurrent ovarian cancer. Gynecol Oncol. 2004 Jan;92(1):368-71. PMID: 14751188.
Coley HM, Brooks N, Phillips DH, et al. The role of the N-(hydroxymethyl)melamines as antitumour agents: mechanism of action studies. Biochem Pharmacol. 1995 May 11;49(9):1203-12. PMID: 7763301.
Hansen LA, Hughes TE. Altretamine. DICP. 1991 Feb;25(2):146-52. PMID: 1905441.
Synthetic vasopressin derivative; V2R agonist.<...
Enalapril metabolite; ACE inhibitor.
Triterpene saponin found in species of Panax.
EGFR, VEGFR inhibitor.
Adenosine A2A antagonist.
Induces apoptosis, DNA cleavage and strand brea...
EGFR inhibitor.
Peptide; NMDA partial agonist.
Organosulfur found in garlic; Microtubule polym...
Fluoroquinolone; topoisomerase IV and bacterial...
Endogenous peptide hormone, counteracts insulin...
HDAC inhibitor. May reduce blood pressure in hy...
Diterpene found in brewed, unfiltered coffee; F...
Synthetic nitrile compound
PRMT5/MTA complex inhibitor
Mast cell destabilizer; potential TRP antagonis...
CDK1/2 inhibitor.
NSAID; COX-1/2 and PDE inhibitor.
Inhibitor of coronaviruses