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Amantadine Sulfate

Amantadine Sulfate

Product ID A4803
Cas No. 31377-23-8
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $75.10 In stock
25 g $142.80 In stock
100 g $300.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Amantadine exhibits neuroprotective and antiviral activity. Amantadine directly inhibits the viral M2 proton channel. This compound is also used to treat Parkinson’s disease; it inhibits monoamine oxidase A (MAO-A), α7 nicotinic acetylcholine receptors (nAChRs), norepinephrine transporters (NET), and NMDA receptors (through acceleration of channel closure).

Product Info

Cas No.

31377-23-8

Purity

≥98%

Formula

(C10H17N)2 • H2SO4

Formula Wt.

400.58

Chemical Name

Tricyclo[3.3.1.13,7]decan-1-amine sulfate

IUPAC Name

adamantan-1-amine;sulfuric acid

Synonym

PK-Merz, Trivaline

Melting Point

300°C

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A4803 MSDS PDF

Info Sheet

A4803 Info Sheet PDF

References

Sommerauer C, Rebernik P, Reither H, et al. The noradrenaline transporter as site of action for the anti-Parkinson drug amantadine. Neuropharmacology. 2012 Mar;62(4):1708-16. PMID: 22155208.

Jing X, Ma C, Ohigashi Y, et al. Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10967-72. PMID: 18669647.

Blanpied TA, Clarke RJ, Johnson JW. Amantadine inhibits NMDA receptors by accelerating channel closure during channel block. J Neurosci. 2005 Mar 30;25(13):3312-22. PMID: 15800186.

Pearce J. Mechanism of action of amantadine. Br Med J. 1971 Aug 26;3(5773):529. PMID: 4327681.

Custom Order

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