Description
AMG-208 is an inhibitor of c-MET and Ron that exhibits anticancer chemotherapeutic activity in prostate cancer models in vitro and in vivo.
AMG-208
Product ID A4924
Cas No. 1002304-34-8
Purity ≥98%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 1002304-34-8 |
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| Purity | ≥98% |
| Formula | C22H17N5O2 |
| Formula Wt. | 383.40 |
| Chemical Name | 7-methoxy-4-[(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline |
| IUPAC Name | 7-methoxy-4-[(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline |
| Synonym | AMG208; AMG 208 |
| Solubility | DMSO 0.25 mg/mL (0.65 mM) Water Insoluble Ethanol Insoluble |
| Appearance | White to off white powder |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Liu X, Newton RC, Scherle PA. Developing c-MET pathway inhibitors for cancer therapy: progress and challenges. Trends Mol Med. 2010 Jan;16(1):37-45. PMID: 20031486.
Albrecht BK, Harmange JC, Bauer D, et al. Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase. J Med Chem. 2008 May 22;51(10):2879-82. PMID: 18426196.