| Product Unit Size | Cost | Quantity | Stock |
|---|
AMG-232 is an inhibitor of the p53-MDM2 protein-protein interaction.
Studies on a mouse model resulted in activated p53 signaling and inhibited growth of various tumor xenografts. AMG-232 was shown to block DNA synthesis and induce apoptosis in vivo.
| Cas No. | 1352066-68-2 |
|---|---|
| Purity | ≥99% |
| Formula | C28H35Cl2NO5S |
| Formula Wt. | 568.55 |
| IUPAC Name | 2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(2S)-3-methyl-1-propan-2-ylsulfonylbutan-2-yl]-2-oxopiperidin-3-yl]acetic acid |
| Synonym | Navtemadlin |
| Appearance | White crystalline powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet |
|---|
Ye Q, Jiang M, Huang W, et al. Pharmacokinetics and metabolism of AMG-232, a novel bioavailable inhibitor of the MDM2-p53 interaction, in rats, dogs and monkeys: in vitro-in vivo correlation. Xenobiotica. 2015;45(8):681-692. PMID: 25798742
Canon J, Osgood T, Olson S, et al. The MDM2 inhibitor AMG 232 demonstrates robust antitumor efficacy and potentiates the activity of p53-inducing cytotoxic agents. Mol Cancer Ther. 2015 Mar;14(3):649-658. PMID: 25567130