• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Aminopterin

Aminopterin

Product ID A5001
Cas No. 54-62-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $82.70 In stock
25 mg $220.50 In stock
100 mg $606.40 In stock
500 mg $1,378.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Aminopterin is a folic acid analog and derivative of pterin; it is very similar to methotrexate in structure. Aminopterin exhibits anticancer chemotherapeutic and immunosuppressive activities. Like other folic acid analogs, aminopterin inhibits dihydrofolate reductase, depleting nucleotide pools and inhibiting synthesis of DNA and RNA. Aminopterin was one of the first compounds to successfully induce remission in childhood leukemia and was clinically used to treat rheumatoid arthritis, but has since been replaced by methotrexate.

Product Info

Cas No.

54-62-6

Purity

≥98%

Formula

C19H20N8O5

Formula Wt.

440.41

Chemical Name

N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid

IUPAC Name

2-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid

Synonym

4-Aminofolic acid

Melting Point

230-235°C (dec)

Solubility

Soluble in DMSO or 2 N NaOH (50mg/mL).

Appearance

Dark Yellow-Brown Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A5001 MSDS PDF

Info Sheet

A5001 Info Sheet PDF

References

Visentin M, Zhao R, Goldman ID. The antifolates. Hematol Oncol Clin North Am. 2012 Jun;26(3):629-48. PMID: 22520983.

McGuire JJ. Anticancer antifolates: current status and future directions. Curr Pharm Des. 2003;9(31):2593-613. PMID: 14529544.

Baggott JE, Morgan SL, Ha TS, et al. Antifolates in rheumatoid arthritis: a hypothetical mechanism of action. Clin Exp Rheumatol. 1993 Mar-Apr;11 Suppl 8:S101-5. PMID: 8324932.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • O9398

    Oxymetazoline Hydrochloride

    Imidazoline derivative; α1-adrenergic agonist,...

    ≥98%
  • K0034

    Kahweol Eicosanate

    Diterpene found in coffee beans.

    ≥98%
  • A2500

    AG-1478

    EGFR inhibitor.

    ≥98%
  • T3185

    Thymidine

    Pyrimidine nucleoside base, pairs with adenosin...

    ≥98%
  • T8020

    Tuftsin

    Tetrapeptide, IgG Fc region derivative; Nrp1 ag...

    ≥95%
  • A6800

    AR-A014418

    GSK-3β inhibitor.

    ≥98%
  • H3277

    Histrelin Acetate

    Peptide, GnRH analog; GnRH agonist.
    ≥95%
  • M1679

    Methysticin

    Kavalactone originally found in Piper methystic...

    ≥98%
  • F1654

    Fenoldopam Mesylate

    Benzazepine derivative; D1 partial agonist, pot...

    ≥98%
  • C691325

    Cridanimod

    STING agonist

    ≥99%
  • S1872

    Sesamin

    Lignin found in Sesamin indicum;

    ≥98%
  • B8275

    n-Butyric Acid

    Fatty acid found in dairy products; HDAC inhibi...

    ≥98%
  • A5059

    Amoxapine

    5-HT2/3/6/7, D2/3/4, histamine H1, α1-adrenerg...

    ≥98%
  • M5727

    Moguisteine

    Potential ATP-sensitive K+ channel blocker, pot...

    ≥98%
  • O9210

    Oxcarbazepine

    α4β2 nAChR desensitizer, delayed-rectifier vo...

    ≥98%
  • A5132

    Amikacin Disulfate

    Aminoglycoside; protein translation inhibitor.<...

    ≥98%
  • F1652

    Fenbufen

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • O4102

    Okadaic Acid Ammonium

    Shellfish toxin produced by dinoflagellates and...

    ≥98%
  • A706840

    ARV-825

    Degrades of BET proteins.

    ≥99%
  • P1760

    Peptide T

    Peptide fragment of HIV-1 gp120.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only