LKT Labs

Biochemicals for Life Science Research

Angiotensin II, human

Product ID A5277
Cas No. 68521-88-0
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $213.80 In stock
10 mg $356.40 In stock
25 mg $712.80 In stock
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Description

Angiotensin II (AT II) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). AT II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels; this results in contraction and vasoconstriction, increasing blood pressure. AT II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney. Here, AT II increases reabsorption of Na+ and HCO3- and excretion of H+, increasing blood volume and pH and further increasing blood pressure.

Product Info

Cas No.

68521-88-0
Purity

≥95%
Formula

C50H71N13O12
Formula Wt.

1046.19
IUPAC Name

acetic acid;3-amino-4-[[1-[[1-[[1-[[1-[[1-[2-[(1-carboxy-2-phenylethyl) carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]- 3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl] amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1- oxopentan-2-yl]amino]-4-oxobutanoic acid
Synonym

Hypertensin II
Solubility

Soluble in water or 5% acetic acid.

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A5277 MSDS PDF
Info Sheet

A5277 Info Sheet PDF

References

De Giusti VC, Ciancio MC, Orlowski A, et al. Modulation of the cardiac sodium/bicarbonate cotransporter by the renin angiotensin aldosterone system: pathophysiological consequences. Front Physiol. 2014 Jan 17;4:411. PMID: 24478712.

Moon JY. Recent Update of Renin-angiotensin-aldosterone System in the Pathogenesis of Hypertension. Electrolyte Blood Press. 2013 Dec;11(2):41-45. PMID: 24627703.

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