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Apelin-13, human/cow

Product ID A6017
Cas No. 217082-60-5
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $118.70 Please Inquire
1 mg $200.20 Please Inquire
2.5 mg $355.90 Please Inquire
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  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
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Description

Apelin-13 is an endogenous peptide that exhibits neuroprotective and pro-angiogenic activities. Apelin-13 binds apelin receptors (APJ receptors) that heterodimerize with bradykinin receptors; upon binding, this complex signals for increases in phosphorylation of eNOS, activation of PKC, and cellular proliferation. Apelin-13 is also involved in the regulation of water balance, food intake, nociception, and cardiovascular responses. In vivo and in vitro, apelin-13 increases myocardial glucose uptake and GLUT4 membrane translocation in an AMPK-dependent manner. In animal models of ischemia/reperfusion, apelin-13 decreases neurological deficits, infarct volume, and brain edema, and also downregulates expression of Bax and caspase 3 through activation of the PI3K/Akt signaling pathway. Additionally, apelin-13 promotes proliferation, migration, and tube formation in myocardial microvascular endothelial cells.

Product Info

Cas No.

217082-60-5

Purity

≥95%

Formula

C69H111N23O16S

Formula Wt.

1550.86

Solubility

Soluble in ethanol (20 mg/mL). Soluble in DMSO (30 mg/mL). Soluble in PBS (10 mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A6017 MSDS PDF

Info Sheet

A6017 Info Sheet PDF

References

Yang Y, Zhang X, Cui H, et al. Apelin-13 protects the brain against ischemia/reperfusion injury through activating PI3K/Akt and ERK1/2 signaling pathways. Neurosci Lett. 2014 Mar 29;568C:44-49. [Epub ahead of print]. PMID: 24686182.

Bo B, Lulu L, Ning Z, et al. Heterodimerization of human apelin and bradykinin 1 receptors: Novel signal transduction characteristics. Cell Signal. 2014 Mar 29. pii: S0898-6568(14)00124-7. [Epub ahead of print]. PMID: 24686079.

Yang X, Zhu W, Zhang P, et al. Apelin-13 stimulates angiogenesis by promoting cross talk between AMP-activated protein kinase and Akt signaling in myocardial microvascular endothelial cells. Mol Med Rep. 2014 May;9(5):1590-6. PMID: 24573187.

Xu S, Han P, Huang M, et al. In vivo, ex vivo, and in vitro studies on apelin's effect on myocardial glucose uptake. Peptides. 2012 Oct;37(2):320-6. PMID: 22906703.

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