• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Awaiting product image

Asparaginase

Product ID A7460
Cas No. 9015-68-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $63.60 In stock
5 mg $136.70 In stock
25 mg $364.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Asparaginase is an enzyme that catalyzes the hydrolysis of asparagine to aspartate and ammonia, depleting asparagine levels and inhibiting cell growth; it is commonly used as an anticancer chemotherapeutic and anti-angiogenic compound in the treatment of leukemia. Asparaginase inhibits proliferation of acute myelogenous leukemia (AML) cells, inducing apoptosis mediated by apoptosis-inducing factor (AIF). Asparaginase decreases β1 integrin binding and phosphorylation of FAK, inducing autophagy; this decreases microvascular endothelial cell tube formation and inhibits invasion of ovarian cancer cells. In clinical settings, asparaginase may induce thrombotic effect, as administration often results in depletion of anti-thrombin, and it may also increase serum triglycerides.

Product Info

Cas No.

9015-68-3

Purity

≥98%

Formula

C1377H2208N382O442S17

Formula Wt.

31731.9

Synonym

Colaspase

Solubility

Soluble in water (1 mg/mL).

Appearance

White or almost white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

A7460 MSDS PDF

Info Sheet

A7460 Info Sheet PDF

References

He Y, Li B, Zhang H, et al. L-asparaginase induces in AML U937 cells apoptosis via an AIF-mediated mechanism. Front Biosci (Landmark Ed). 2014 Jan 1;19:515-27. PMID: 24389199.

Yu M, Henning R, Walker A, et al. L-asparaginase inhibits invasive and angiogenic activity and induces autophagy in ovarian cancer. J Cell Mol Med. 2012 Oct;16(10):2369-78. PMID: 22333033.

Nomme J, Su Y, Konrad M, et al. Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis. Biochemistry. 2012 Aug 28;51(34):6816-26. PMID: 22861376.

Mitchell L, Andrew M, Hanna K, et al. Trend to efficacy and safety using antithrombin concentrate in prevention of thrombosis in children receiving l-asparaginase for acute lymphoblastic leukemia. Results of the PAARKA study. Thromb Haemost. 2003 Aug;90(2):235-44. PMID: 12888870.

Cremer P, Lakomek M, Beck W, et al. The effect of L-asparaginase on lipid metabolism during induction chemotherapy of childhood lymphoblastic leukaemia. Eur J Pediatr. 1988 Jan;147(1):64-7. PMID: 3422190.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C0148

    Calcitonin, human

    Endogenous neuropeptide hormone, lowers extrace...

    ≥95%
  • N3520

    Nifursol

    Nitrofuran, livestock antibiotic.

    ≥98%
  • G7344

    GSK-2334470

    PI3K and PDK1 inhibitor.

    ≥99%, ≥99%ee
  • N1858

    Neosolaniol

    Type A trichothecene mycotoxin produced by Fusa...

    ≥98%
  • B4402

    Blasticidin S Hydrochloride

    Protein translation inhibitor.

    ≥98%
  • A5035

    5-Aminosalicylic Acid

    Salicylic acid derivative; PPARγ agonist, pote...

    ≥98%
  • S0049

    Salmon Calcitonin Acetate

    Peptide, involved in feeding behavior and insul...

    ≥95%
  • P3076

    PHT-427

    PDK1 and Akt inhibitor.

    ≥98%
  • T1676

    L-Tetrahydropalmatine

    Alkaloid found in Corydalis and Stephania; D1/2...

    ≥98%
  • T7033

    Trifluoperazine Dihydrochloride

    Phenothiazine; D1/2 and α1-adrenergic antagoni...

    ≥98%
  • S6000

    Sparfloxacin

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • C5773

    Cortistatin-14

    Endogenous neuropeptide, somatostatin analog; s...

    ≥95%
  • I7459

    1-Isothiocyanato-8-(methylsulfinyl)-octane

    ITC found in Nasturtium officinale (watercress)...

    ≥98%
  • C5972

    Corynoline

    Alkaloid compound originally found in Corydalis...

    ≥98%
  • T0140

    TAK-632

    RAF inhibitor.

    ≥99%
  • L3250

    D-Limonene

    Terpene found in the rind of various citrus fru...

    ≥97%
  • O9497

    Oxytocin

    Endogenous neuropeptide hormone, involved in so...

    ≥95%
  • M5727

    Moguisteine

    Potential ATP-sensitive K+ channel blocker, pot...

    ≥98%
  • P6802

    Pranoprofen

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • P8270

    Purvalanol A

    Purine derivative; CDK inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only