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Asparaginase

Product ID A7460
Cas No. 9015-68-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $63.60 In stock
5 mg $136.70 In stock
25 mg $364.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Asparaginase is an enzyme that catalyzes the hydrolysis of asparagine to aspartate and ammonia, depleting asparagine levels and inhibiting cell growth; it is commonly used as an anticancer chemotherapeutic and anti-angiogenic compound in the treatment of leukemia. Asparaginase inhibits proliferation of acute myelogenous leukemia (AML) cells, inducing apoptosis mediated by apoptosis-inducing factor (AIF). Asparaginase decreases β1 integrin binding and phosphorylation of FAK, inducing autophagy; this decreases microvascular endothelial cell tube formation and inhibits invasion of ovarian cancer cells. In clinical settings, asparaginase may induce thrombotic effect, as administration often results in depletion of anti-thrombin, and it may also increase serum triglycerides.

Product Info

Cas No.

9015-68-3

Purity

≥98%

Formula

C1377H2208N382O442S17

Formula Wt.

31731.9

Synonym

Colaspase

Solubility

Soluble in water (1 mg/mL).

Appearance

White or almost white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

A7460 MSDS PDF

Info Sheet

A7460 Info Sheet PDF

References

He Y, Li B, Zhang H, et al. L-asparaginase induces in AML U937 cells apoptosis via an AIF-mediated mechanism. Front Biosci (Landmark Ed). 2014 Jan 1;19:515-27. PMID: 24389199.

Yu M, Henning R, Walker A, et al. L-asparaginase inhibits invasive and angiogenic activity and induces autophagy in ovarian cancer. J Cell Mol Med. 2012 Oct;16(10):2369-78. PMID: 22333033.

Nomme J, Su Y, Konrad M, et al. Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis. Biochemistry. 2012 Aug 28;51(34):6816-26. PMID: 22861376.

Mitchell L, Andrew M, Hanna K, et al. Trend to efficacy and safety using antithrombin concentrate in prevention of thrombosis in children receiving l-asparaginase for acute lymphoblastic leukemia. Results of the PAARKA study. Thromb Haemost. 2003 Aug;90(2):235-44. PMID: 12888870.

Cremer P, Lakomek M, Beck W, et al. The effect of L-asparaginase on lipid metabolism during induction chemotherapy of childhood lymphoblastic leukaemia. Eur J Pediatr. 1988 Jan;147(1):64-7. PMID: 3422190.

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