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Asperosaponin VI

Asperosaponin VI

Product ID A7461
Cas No. 39524-08-8
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $92.00 In stock
25 mg $183.60 In stock
100 mg $612.70 In stock
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  • Description
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Description

Asperosaponin VI is a triterpene saponin found in the Dipsacus asper plant. Asperosaponin VI displays cardioprotective and antioxidative activities. In animal models, this compound protects the heart from ischemic injury by decreasing levels of lactate dehydrogenase, creatine kinase, glutamic oxalacetic transaminase, and cardiac troponin T, and increasing levels of radical scavenging enzymes such as glutathione peroxidase and superoxide dismutase. Asperosaponin VI also inhibits apoptosis in hypoxic cardiac myocytes, increasing the Bcl-2/Bax ratio and decreasing caspase-3 expression. In an animal model of cardiac fibrosis, this compound improves left ventricle systolic pressure and left ventricle end-diastolic pressure by decreasing expression of pro-inflammatory cytokines IL-6 and TNF-α.

Product Info

Cas No.

39524-08-8

Purity

≥98%

Formula

C47H76O18

Formula Wt.

929.10

Chemical Name

[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl] (4aS,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-10-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate

IUPAC Name

[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl] (6aS,9R)-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-10-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate

Synonym

Akebia Saponin D, CID 14284436

Appearance

White Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A7461 MSDS PDF

Info Sheet

A7461 Info Sheet PDF

References

Li C, Gao Y, Tian J, et al. Long-term oral Asperosaponin VI attenuates cardiac dysfunction, myocardial fibrosis in a rat model of chronic myocardial infarction. Food Chem Toxicol. 2012 May;50(5):1432-8. PMID: 22343037.

Li C, Tian J, Li G, et al. Asperosaponin VI protects cardiac myocytes from hypoxia-induced apoptosis via activation of the PI3K/Akt and CREB pathways. Eur J Pharmacol. 2010 Dec 15;649(1-3):100-7. PMID: 20863824.

Li C, Liu Z, Tian J, et al. Protective roles of Asperosaponin VI, a triterpene saponin isolated from Dipsacus asper Wall on acute myocardial infarction in rats. Eur J Pharmacol. 2010 Feb 10;627(1-3):235-41. PMID: 19909736.

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