• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Axitinib

Axitinib

Product ID A9435
Cas No. 319460-85-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $52.50 In stock
25 mg $112.60 In stock
100 mg $188.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Axitinib is an inhibitor of VEGFR that exhibits anticancer chemotherapeutic and anti-angiogenic activities. Axitinib is currently in clinical trials as a potential treatment for renal cell carcinoma. In vitro, axitinib increases levels of CD8+ T cells and decreases levels of myeloid-derived suppressor cells, inhibiting proliferation and increasing apoptosis. In vivo, this compound inhibits expression of iNOS, arginase, IL-6, TNF-α, and IFN-γ, increasing apoptosis and inhibiting tumor growth. In animal models of lung adenocarcinoma, axitinib decreases tumor vasculature and lesion growth.

Product Info

Cas No.

319460-85-0

Purity

≥98%

Formula

C22H18N4OS

Formula Wt.

386.47

Chemical Name

N-methyl-2-[[3-[(1E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl]sulfanyl]benzamide

IUPAC Name

N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl] benzamide

Melting Point

213-224°C

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A9435 MSDS PDF

Info Sheet

A9435 Info Sheet PDF

References

Zhang X, Fang X, Gao Z, et al. Axitinib, a selective inhibitor of vascular endothelial growth factor receptor, exerts an anticancer effect in melanoma through promoting antitumor immunity. Anticancer Drugs. 2014 Feb;25(2):204-11. PMID: 24135499.

Gross-Goupil M, François L, Quivy A, et al. Axitinib: A Review of its Safety and Efficacy in the Treatment of Adults with Advanced Renal Cell Carcinoma. Clin Med Insights Oncol. 2013 Oct 29;7:269-277. PMID: 24250243.

Majeti BK, Lee JH, Simmons BH, et al. VEGF is an important mediator of tumor angiogenesis in malignant lesions in a genetically engineered mouse model of lung adenocarcinoma. BMC Cancer. 2013 Apr 29;13(1):213. [Epub ahead of print]. PMID: 23627488.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C3263

    Ciprofloxacin Hydrochloride Monohydrate

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • S1604

    Secretin Acetate

    Endogenous peptide hormone, involved in feeding...

    ≥95%
  • C0221

    Caffeine

    Xanthine alkaloid found in coffee, tea, and oth...

    ≥98%
  • S0245

    Salmeterol

    β2-adrenergic agonist.

    ≥98%
  • O486181

    Omeprazole Related Compound B

    Impurity of omeprazole

    ≥99%
  • B5609

    Boc-GRR-AMC

    Peptide, protease substrate.

    ≥98%
  • S8144

    Sulfadoxine

    Sulfonamide; dihydropteroate synthase inhibitor...

    ≥98%
  • R0272

    Rasagiline Mesylate

    MAO-A/B inhibitor.

    ≥98%
  • T9945

    Tylosin Tartrate

    Macrolide; peptidyl transferase inhibitor, prot...

    ≥90%
  • A9601

    AZD-5363

    AKT inhibitor, potential ROCK, p70S6K, PKA, MKK...

    ≥99%, ≥99%ee
  • M7200

    MS436

    BRD4 inhibitor.

    ≥99%
  • V3355

    Vindoline

    Semi-synthetic vinca alkaloid found in Catharan...

    ≥98%
  • S0170

    Sarafloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥95%
  • SB5776

    Snake venom – Bothrops alternatus (urutu)

    Snake venom found in Bothrops alternatus urutu....

    ≥98%
  • A985130

    AZD-7762

    CHK1 inhibitor.

    ≥98%
  • G4598

    Glycyrrhizic Acid Ammonium Hydrate

    Triterpene glycoside found in Glycyrrhiza; 11β...

    ≥93%
  • M3353

    Minocycline Hydrochloride

    Tetracycline; protein translation inhibitor, MM...

    ≥98%
  • P7103

    Praziquantel

    Alters membrane permeability and Ca2+ signaling...

    ≥98%
  • T3132

    Thiazovivin

    ROCK inhibitor.

    ≥98%
  • T1006

    10-Acetoacetyl Paclitaxel

    Synthesis impurity

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only