Description
BAY-1895344 is an inhibitor of ataxia telangiectasia and Rad3-related kinase (ATR), a chromatin-remodeling protein that senses DNA damage and activates the DNA damage checkpoint to induce cell cycle arrest.
| Product Unit Size | Cost | Quantity | Stock |
|---|
BAY-1895344 is an inhibitor of ataxia telangiectasia and Rad3-related kinase (ATR), a chromatin-remodeling protein that senses DNA damage and activates the DNA damage checkpoint to induce cell cycle arrest.
| Cas No. | 1876467-74-1 |
|---|---|
| Purity | ≥99% |
| Formula | C20H21N7O |
| Formula Wt. | 375.44 |
| IUPAC Name | 2-[(3R)-3-Methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine |
| Synonym | BAY 1895344, BAY1895344 |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Wengner A., Siemeister G. et al. ATR inhibitor BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride in preclinical tumor models. 77(13 Suppl):Abstract nr 836 (2017).
c-MET inhibitor.
Abl, c-Kit, PDGFR inhibitor.
Hedgehog and Smo agonist.
Endogenous peptide; actin polymerization inhibi...
GABA-A antagonist.
Cembranoid diterpene found in Sarcophyton glauc...
Histamine H2 inverse agonist.
Chloramphenicol derivative; protein translation...
Imidazole; 14-α demethylase inhibitor, potenti...
ACE inhibitor.
Diterpene component of vitamin A, differentiati...
Kavalactone originally found in Piper methystic...
BTK inhibitor.
Endogenous biogenic amine, norepinephrine-like ...
Semi-synthetic peptide, melanocortin analog; MC...
Sulfur analog of furan found in cooked meat pro...
Alkaloid found in Cephalotaxus; ribosomal prote...
NSAID; COX-1/2 and PDE inhibitor.
Selective inhibitor of protein kinase C (PKC).<...
Mycotoxin produced by Aspergillus; carcinogen.<...