LKT Labs

Biochemicals for Life Science Research

Bleomycin Sulfate

Bleomycin Sulfate

Product ID B4518
Cas No. 9041-93-4
Purity ≥90%
Product Unit SizeCostQuantityStock
5 mg $200.10 In stock
10 mg $275.50 In stock
25 mg $561.40 In stock
100 mg $1,735.80 In stock
Bulk Quote

Quicklinks

Description

This product is a mixture of bleomycin sulfate salts; bleomycin A2 is pictured. Bleomycin is an anticancer chemotherapeutic that binds DNA and induces DNA cleavage and strand breaks; it is highly toxic. Bleomycin A5 is clinically used to treat lymphomas, squamous cell carcinomas, and testicular cancer. Additionally, this compound induces apoptosis, alters cell cycle regulation, inhibits proliferation, and decreases tumor size in cellular and animal models of hemangioma. Bleomycin A2 inhibits viral reproduction of human papilloma virus. Bleomycin A2 also cleaves DNA at 5’-GT sequences (including in telomeres) and induces tRNA cleavage. Bleomycin may also inhibit thioredoxin reductase.

Product Info

Cas No.

9041-93-4
Purity

≥90%
Formula

C55H84N17O21S3 • H2SO4

Formula Wt.

1512.63
IUPAC Name

3-[[2-[2-[2-[[2-[[4-[[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2R,3S,4S,5R,6R)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]ethyl]-1,3-thiazol-4-yl]-1,3-thiazole-4-carbonyl]amino]propyl-dimethylsulfanium;hydrogen sulfate
Synonym

Blenoxane, Blexane

Melting Point

71°C

Solubility

Soluble in water ( 20 mg/mL), DMSO (100 mg/mL), methanol.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

B4518 MSDS PDF
Info Sheet

B4518 Info Sheet PDF

References

Ramírez-Fort MK, Au SC, Javed SA, et al. Management of cutaneous human papillomavirus infection: pharmacotherapies. Curr Probl Dermatol. 2014;45:175-85. PMID: 24643186.

Li P, Li DF, Guo ZT, et al. Therapeutic mechanism of bleomycin A5 on infancy hemangioma: an experimental study. Zhonghua Kou Qiang Yi Xue Za Zhi. 2013 Jan;48(1):18-22. PMID: 23534516.

Nguyen HT, Murray V. The DNA sequence specificity of bleomycin cleavage in telomeric sequences in human cells. J Biol Inorg Chem. 2012 Dec;17(8):1209-15. PMID: 22961398.

Yang Y, Sun M, Ma Q, et al. Bleomycin A5 sclerotherapy for cervicofacial lymphatic malformations. J Vasc Surg. 2011 Jan;53(1):150-5. PMID: 20843632.

Liu Y, Wu F, Zou G. Electrophoresis mobility shift assay and biosensor used in studying the interaction between bleomycin A5 and DNA. Anal Chim Acta. 2007 Sep 19;599(2):310-4. PMID: 17870295.

Vorobjev PE, Smith JB, Pyshnaya IA, et al. Site-specific cleavage of RNA and DNA by complementary DNA--bleomycin A5 conjugates. Bioconjug Chem. 2003 Nov-Dec;14(6):1307-13. PMID: 14624648.

Abraham AT, Lin JJ, Newton DL, et al. RNA cleavage and inhibition of protein synthesis by bleomycin. Chem Biol. 2003 Jan;10(1):45-52. PMID: 12573697.

Hecht SM. Bleomycin: new perspectives on the mechanism of action. J Nat Prod. 2000 Jan;63(1):158-68. PMID: 10650103.

Marcon L, Zhang X, Hales BF, et al. Effects of chemotherapeutic agents for testicular cancer on rat spermatogonial stem/progenitor cells. J Androl. 2011 Jul-Aug;32(4):432-443. PMID: 21088230.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M0114

    Madecassic Acid

    Downregulates LPS-stimulated expression of pro-...

    ≥95%
  • O2144

    Ofloxacin

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • M017545

    Manumycin A

    Natural antibiotic found in Streptomyces parvul...

    ≥98%
  • V1668

    Vemurafenib

    B-Raf inhibitor.

    ≥98%
  • T3038

    Thienylnonanyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥98%
  • T3034

    Thienylethyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥98%
  • P2817

    Phentolamine Hydrochloride

    ATP-sensitive K+ channel activator, α-adrenerg...

    ≥98%
  • I0902

    Icaritin

    Flavonoid found in Epimedium.

    ≥98%
  • X1753

    Xenopsin

    Peptide hormone, neurotensin analog found in am...

    ≥95%
  • D1792

    Dextromethorphan Hydrobromide Hydrate

    σ1/2and μ/κ/δ-OR agonist, α3β4/α4β2/α7...

    ≥98%
  • A8644

    AVL-292

    BTK inhibitor.

    ≥98%
  • A2052

    Aflatoxin M1

    Mycotoxin produced by species of Aspergillus; D...

    ≥98%
  • C1878

    Cetrimide

    Mixture of quaternary ammonium salts, cationic ...

    ≥98%
  • K9200

    KX1-004

    Indole; Src inhibitor.

    ≥98%
  • G4480

    Glucagon, human

    Endogenous peptide hormone, counteracts insulin...

    ≥95%
  • B4976

    BMS-794833

    MET, VEGFR2, Ron, Axl, FLT3 inhibitor.

    ≥98%
  • G5752

    Gonadorelin Acetate

    Synthetic peptide, GnRH derivative; GnRH agonist.
    ≥95%
  • G4596

    Glycidamide

    Epoxide metabolite of acrylamide, induces DNA a...

    ≥98%
  • R8179

    Rutaecarpine, synthetic

    Found in Evodia rutaecarpa; potential cAMP, 3β...

    ≥98%
  • C0249

    Calcitonin Gene Related Peptide (8-37), rat

    Endogenous calcitonin-family peptide frgament, ...

    ≥95%