LKT Labs

Biochemicals for Life Science Research

Bleomycin Sulfate

Bleomycin Sulfate

Product ID B4518
Cas No. 9041-93-4
Purity ≥90%
Product Unit SizeCostQuantityStock
5 mg $200.00 In stock
10 mg $276.00 In stock
25 mg $561.00 In stock
100 mg $1,736.00 In stock
Bulk Quote

Quicklinks

Description

This product is a mixture of bleomycin sulfate salts; bleomycin A2 is pictured. Bleomycin is an anticancer chemotherapeutic that binds DNA and induces DNA cleavage and strand breaks; it is highly toxic. Bleomycin A5 is clinically used to treat lymphomas, squamous cell carcinomas, and testicular cancer. Additionally, this compound induces apoptosis, alters cell cycle regulation, inhibits proliferation, and decreases tumor size in cellular and animal models of hemangioma. Bleomycin A2 inhibits viral reproduction of human papilloma virus. Bleomycin A2 also cleaves DNA at 5’-GT sequences (including in telomeres) and induces tRNA cleavage. Bleomycin may also inhibit thioredoxin reductase.

Product Info

Cas No.

9041-93-4
Purity

≥90%
Formula

C55H84N17O21S3 • H2SO4

Formula Wt.

1512.63
IUPAC Name

3-[[2-[2-[2-[[2-[[4-[[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2R,3S,4S,5R,6R)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]ethyl]-1,3-thiazol-4-yl]-1,3-thiazole-4-carbonyl]amino]propyl-dimethylsulfanium;hydrogen sulfate
Synonym

Blenoxane, Blexane

Melting Point

71°C

Solubility

Soluble in water ( 20 mg/mL), DMSO (100 mg/mL), methanol.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

B4518 MSDS PDF
Info Sheet

B4518 Info Sheet PDF

References

Ramírez-Fort MK, Au SC, Javed SA, et al. Management of cutaneous human papillomavirus infection: pharmacotherapies. Curr Probl Dermatol. 2014;45:175-85. PMID: 24643186.

Li P, Li DF, Guo ZT, et al. Therapeutic mechanism of bleomycin A5 on infancy hemangioma: an experimental study. Zhonghua Kou Qiang Yi Xue Za Zhi. 2013 Jan;48(1):18-22. PMID: 23534516.

Nguyen HT, Murray V. The DNA sequence specificity of bleomycin cleavage in telomeric sequences in human cells. J Biol Inorg Chem. 2012 Dec;17(8):1209-15. PMID: 22961398.

Yang Y, Sun M, Ma Q, et al. Bleomycin A5 sclerotherapy for cervicofacial lymphatic malformations. J Vasc Surg. 2011 Jan;53(1):150-5. PMID: 20843632.

Liu Y, Wu F, Zou G. Electrophoresis mobility shift assay and biosensor used in studying the interaction between bleomycin A5 and DNA. Anal Chim Acta. 2007 Sep 19;599(2):310-4. PMID: 17870295.

Vorobjev PE, Smith JB, Pyshnaya IA, et al. Site-specific cleavage of RNA and DNA by complementary DNA--bleomycin A5 conjugates. Bioconjug Chem. 2003 Nov-Dec;14(6):1307-13. PMID: 14624648.

Abraham AT, Lin JJ, Newton DL, et al. RNA cleavage and inhibition of protein synthesis by bleomycin. Chem Biol. 2003 Jan;10(1):45-52. PMID: 12573697.

Hecht SM. Bleomycin: new perspectives on the mechanism of action. J Nat Prod. 2000 Jan;63(1):158-68. PMID: 10650103.

Marcon L, Zhang X, Hales BF, et al. Effects of chemotherapeutic agents for testicular cancer on rat spermatogonial stem/progenitor cells. J Androl. 2011 Jul-Aug;32(4):432-443. PMID: 21088230.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S291333

    Shikonin

    Natural anthraquinone derivative

    ≥98%
  • C5870

    Corosolic Acid

    Pentacyclic triterpene found in the Banaba plan...

    ≥98%
  • A5281

    Angiotensin II (4-8), human

    Endogenous peptide fragment, involved in vasoco...

    ≥95%
  • B1879

    Betamethasone Valerate

    Synthetic steroid hormone; glucocorticoid agoni...

    ≥98%
  • M4004

    MK-2461

    MET, FGFR, PDGFR inhibitor.

    ≥99%
  • C0140

    Calcitonin, eel

    Endogenous neuropeptide hormone, lowers extrace...

    ≥95%
  • T3585

    Tivozanib

    VEGFR1/2/3, c-Kit, PDGFR inhibitor.

    ≥98%
  • E7579

    Estramustine Phosphate Disodium

    Nitrogen mustard and estradiol derivative; micr...

    ≥95%
  • N1984

    Neuropeptide FF

    Endogenous RF-amide peptide, involved in nocice...

    ≥95%
  • I7757

    Itopride Hydrochloride

    AChE inhibitor, D2 antagonist.

    ≥98%
  • A0501

    Abamectin

    Macrocyclic lactone avermectin; GABA antagonist...

    ≥70%
  • Z161025

    β-Zearalenol

    Mycotoxin that has structural similarity to est...

    ≥98%
  • A5217

    trans-Anethole

    Phenylpropene derivative found in essential oil...

    ≥98%
  • C822706

    Curvularin

    Macrocyclic lactone.

    ≥98%
  • L0248

    Laminin Peptide YIGSR

    Laminin-derived peptapeptide.

    ≥98%
  • G0245

    Gallocatechin Gallate

    Polyphenol found in Camilla sinensis; HIV integ...

    ≥98%
  • P3542

    PIK-93

    p110α and p110γ PI3K inhibitor.

    ≥98%
  • S336507

    Simufilam Dihydrochloride

    Unlikely to reverse Alzheimer’s

    ≥98%
  • E4444

    Ellagic Acid

    Phenol found in various fruits; HDAC modulator....

    ≥98%
  • P1869

    Perindopril Erbumine

    ACE inhibitor.

    ≥95%