LKT Labs

Biochemicals for Life Science Research

Bleomycin Sulfate

Bleomycin Sulfate

Product ID B4518
Cas No. 9041-93-4
Purity ≥90%
Product Unit SizeCostQuantityStock
5 mg $200.10 In stock
10 mg $275.50 In stock
25 mg $561.40 In stock
100 mg $1,735.80 In stock
Bulk Quote

Quicklinks

Description

This product is a mixture of bleomycin sulfate salts; bleomycin A2 is pictured. Bleomycin is an anticancer chemotherapeutic that binds DNA and induces DNA cleavage and strand breaks; it is highly toxic. Bleomycin A5 is clinically used to treat lymphomas, squamous cell carcinomas, and testicular cancer. Additionally, this compound induces apoptosis, alters cell cycle regulation, inhibits proliferation, and decreases tumor size in cellular and animal models of hemangioma. Bleomycin A2 inhibits viral reproduction of human papilloma virus. Bleomycin A2 also cleaves DNA at 5’-GT sequences (including in telomeres) and induces tRNA cleavage. Bleomycin may also inhibit thioredoxin reductase.

Product Info

Cas No.

9041-93-4
Purity

≥90%
Formula

C55H84N17O21S3 • H2SO4

Formula Wt.

1512.63
IUPAC Name

3-[[2-[2-[2-[[2-[[4-[[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2R,3S,4S,5R,6R)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]ethyl]-1,3-thiazol-4-yl]-1,3-thiazole-4-carbonyl]amino]propyl-dimethylsulfanium;hydrogen sulfate
Synonym

Blenoxane, Blexane

Melting Point

71°C

Solubility

Soluble in water ( 20 mg/mL), DMSO (100 mg/mL), methanol.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

B4518 MSDS PDF
Info Sheet

B4518 Info Sheet PDF

References

Ramírez-Fort MK, Au SC, Javed SA, et al. Management of cutaneous human papillomavirus infection: pharmacotherapies. Curr Probl Dermatol. 2014;45:175-85. PMID: 24643186.

Li P, Li DF, Guo ZT, et al. Therapeutic mechanism of bleomycin A5 on infancy hemangioma: an experimental study. Zhonghua Kou Qiang Yi Xue Za Zhi. 2013 Jan;48(1):18-22. PMID: 23534516.

Nguyen HT, Murray V. The DNA sequence specificity of bleomycin cleavage in telomeric sequences in human cells. J Biol Inorg Chem. 2012 Dec;17(8):1209-15. PMID: 22961398.

Yang Y, Sun M, Ma Q, et al. Bleomycin A5 sclerotherapy for cervicofacial lymphatic malformations. J Vasc Surg. 2011 Jan;53(1):150-5. PMID: 20843632.

Liu Y, Wu F, Zou G. Electrophoresis mobility shift assay and biosensor used in studying the interaction between bleomycin A5 and DNA. Anal Chim Acta. 2007 Sep 19;599(2):310-4. PMID: 17870295.

Vorobjev PE, Smith JB, Pyshnaya IA, et al. Site-specific cleavage of RNA and DNA by complementary DNA--bleomycin A5 conjugates. Bioconjug Chem. 2003 Nov-Dec;14(6):1307-13. PMID: 14624648.

Abraham AT, Lin JJ, Newton DL, et al. RNA cleavage and inhibition of protein synthesis by bleomycin. Chem Biol. 2003 Jan;10(1):45-52. PMID: 12573697.

Hecht SM. Bleomycin: new perspectives on the mechanism of action. J Nat Prod. 2000 Jan;63(1):158-68. PMID: 10650103.

Marcon L, Zhang X, Hales BF, et al. Effects of chemotherapeutic agents for testicular cancer on rat spermatogonial stem/progenitor cells. J Androl. 2011 Jul-Aug;32(4):432-443. PMID: 21088230.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E5057

    Emodin

    Anthraquinone found in various plant sources; C...

    ≥95%
  • T3039

    Thienyloctyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥97%
  • L9602

    LY-2874455

    FGFR inhibitor.

    ≥98%
  • C2945

    Chlorophyllin Sodium-Copper Salt

    Semi-synthetic derivative of chlorophyll; food ...

    USP 28
  • W5726

    Wogonin

    Flavonoid found in Scutellaria; CDK9 inhibitor....

    ≥98%
  • V9228

    VX-765

    NLRP3 and caspase-1 inhibitor.

    ≥98%
  • B7977

    Butylated Hydroxytoluene

    Antioxidative food and cosmetics additive.

    ≥99%
  • T5996

    Tozasertib

    AurK, FLT3, Abl inhibitor.

    ≥98%
  • I0480

    Ibudilast

    PDE3/5 inhibitor, LTD4 antagonist.

    ≥98%
  • H3277

    Histrelin Acetate

    Peptide, GnRH analog; GnRH agonist.
    ≥95%
  • H6225

    HPGDS-inhibitor-1

    HPGDS inhibitor.

    ≥98%
  • C7992

    CTX-0294885

    Bisaniline pyrimidine; pan-kinase inhibitor.

    ≥98%
  • T2792

    TGX-221

    p110β PI3K inhibitor.
  • D1731

    15,16-Dehydrocafestol

    Diterpene found in roasted coffee.

    ≥98%
  • S1971

    Sertraline Hydrochloride

    FIASMA, SERT and DAT inhibitor, α1-adrenergic ...

    ≥98%
  • G124082

    GDC-0941

    pan-PI3K inhibitor.

    ≥98%
  • Z4900

    ZM-447439 Trihydrate

    AurKA/B inhibitor.

    ≥99%
  • A0962

    Adrenocorticotropic Hormone (1-4)

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • T3197

    L-Thyroxine Sodium Pentahydrate

    Endogenous thyroid hormone T4.

    ≥97%
  • A4523

    Alfuzosin Hydrochloride

    α1-adrenergic antagonist.

    ≥97%