• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
BMS-754807

BMS-754807

Product ID B5072
Cas No. 1001350-96-4
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $67.80 In stock
5 mg $127.90 In stock
10 mg $188.00 In stock
25 mg $338.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

BMS-754807 is an inhibitor of the insulin receptor (InsR) and IGF-1R that exhibits anticancer chemotherapeutic activity. BMS-754807 enhances the efficacy of other co-administered chemotherapeutics, decreasing levels of activated Akt, increasing cleavage of PARP and caspase 3, and inhibiting proliferation in pancreatic ductal adenocarcinoma cells and breast cancer cells in vitro and growth of tumor xenografts in vivo.

Product Info

Cas No.

1001350-96-4

Purity

≥99%

Formula

C23H24FN9O

Formula Wt.

461.51

Chemical Name

(2S)-1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide

IUPAC Name

(2S)-1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide

Synonym

BMS754807; BMS 754807

Solubility

DMSO 92 mg/mL (199.35 mM) Ethanol 92 mg/mL (199.35 mM) Water Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B5072 MSDS PDF

Info Sheet

B5072 Info Sheet PDF

References

Awasthi N, Zhang C, Ruan W, et al. BMS-754807, a small-molecule inhibitor of insulin-like growth factor-1 receptor/insulin receptor, enhances gemcitabine response in pancreatic cancer. Mol Cancer Ther. 2012 Dec;11(12):2644-53. PMID: 23047891.

Hou X, Huang F, Macedo LF, et al. Dual IGF-1R/InsR inhibitor BMS-754807 synergizes with hormonal agents in treatment of estrogen-dependent breast cancer. Cancer Res. 2011 Dec 15;71(24):7597-607. PMID: 22042792.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C4556

    Clofibric Acid

    Metabolite of clofibrate; PPARα agonist.

    ≥98%
  • C7992

    CTX-0294885

    Bisaniline pyrimidine; pan-kinase inhibitor.

    ≥98%
  • B6857

    4’-Bromoflavone

    Nrf2-Keap1-ARE complex activator.

    ≥98%
  • K4401

    KL-1 Peptide

    Peptide, c-Kit ligand fragment.

    ≥95%
  • C7098

    Crystalline peptide

    Dipeptide.

    ≥95%
  • T162051

    Tebipenem

    Broad-spectrum antibiotic

    ≥99%
  • T7860

    TTP 22

    Casein kinase 2 inhibitor.

    ≥98%
  • P0093

    Paclitaxel, semi-synthetic

    Semi-synthetic diterpene originally found in Ta...

    ≥99%
  • C2951

    Chlortetracycline Hydrochloride

    Tetracycline; protein translation inhibitor, MM...

    ≥85%
  • P7628

    Parathyroid Hormone-Related Protein (1-34), human/rat

    Endogenous peptide hormone, increases extracell...

    ≥95%
  • G3351

    Ginkgolic Acid (17:1)

    Mixture of alkylphenols found in Ginkgo; HIV pr...

    ≥98%
  • M1752

    Men 10376

    Peptide; NK2 antagonist.

    ≥95%
  • A6979

    Dihydroartemisinin

    Sesquiterpene lactone derived from Artemesia; m...

    ≥96%
  • N3225

    Nigericin Sodium

    Polyether cationic ionophore.

    ≥98%
  • A7669

    A-type Natriuretic Peptide (1-28), rat

    Endogenous cardiomodulatory peptide; NPR-A agon...

    ≥95%
  • C000078

    C-178

    STING inhibitor

    ≥99%
  • A4675

    Alternariol

    Mycotoxin produced by Alternaria; topoisomerase...

    ≥98%
  • D564088

    10-Acetyl Docetaxel

    Docetaxel impurity

    ≥98%
  • A0002

    A66

    p110α PI3K inhibitor.

    ≥98%
  • A9803

    Azathioprine

    Purine nucleotide analog, mercaptiopurine prodr...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only