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BMS-777607 is an inhibitor of MET and Ron that exhibits anticancer chemotherapeutic activity. BMS-777607 induces polyploidy in breast cancer cells by disrupting spindle formation and inhibiting equatorial alignment and chromosomal segregation. This compound also displays anti-metastatic benefit, inhibiting the motility and invasion of sarcoma cells in vitro and decreasing the number of lung tumor nodules in vivo.
| Cas No. | 1196681-44-3 |
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| Purity | ≥99% |
| Formula | C25H19ClF2N4O4 |
| Formula Wt. | 512.89 |
| Chemical Name | N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide |
| IUPAC Name | N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide |
| Synonym | BMS777607 |
| Solubility | DMSO 47 mg/mL (91.63 mM) Water Insoluble Ethanol Insoluble |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Sharma S, Zeng JY, Zhuang CM, et al. Small-molecule inhibitor BMS-777607 induces breast cancer cell polyploidy with increased resistance to cytotoxic chemotherapy agents. Mol Cancer Ther. 2013 May;12(5):725-36. PMID: 23468529.
Dai Y, Bae K, Pampo C, et al. Impact of the small molecule Met inhibitor BMS-777607 on the metastatic process in a rodent tumor model with constitutive c-Met activation. Clin Exp Metastasis. 2012 Mar;29(3):253-61. PMID: 22286523.