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Camalexin

Camalexin

Product ID C016481
Cas No. 135531-86-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $84.30 In stock
25 mg $324.50 In stock
100 mg $934.50 In stock
250 mg $1,622.40 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Camalexin is a phytoalexin found in various cruciferous plants after exposure to environmental stresses. Studies on acute myeloid leukemia cells show that camalexin selectively decreases cell viability. Several studies have already shown that exposure to camalexin causes cell shrinkage and phospholipid scrambling in the membrane of human erythrocytes. Camalexin treatment of prostate cancer cells indicate that camalexin may be more potent toward the more aggressive strain of cells C4-2 as versus the less aggressive strain LNCaP.

Product Info

Cas No.

135531-86-1

Purity

≥98%

Formula

C11H8N2S

Formula Wt.

200.26

Chemical Name

2-(1H-indol-3-yl)-1,3-thiazole

IUPAC Name

2-(1H-indol-3-yl)-1,3-thiazole

Synonym

3-(1,3-thiazol-2-yl)-1H-indole, 3-(thiazol-2-yl)indole

Melting Point

134-137°C

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C016481 MSDS PDF

Info Sheet

C016481 Info Sheet PDF

References

Yang Y, Wang G, Wu W, et al. Camalexin inducese apoptosis via the ROS-ER stress-mitochondrial apoptosis pathway in AML cells. Oxid Med Cell Longev. 2018 Nov 14;2018:7426950. PMID: 30538806.

Almasry M, Jemaa M, Mischitelli M, et al. Camalexin-induced cell membrane scrambling and cell shrinkage in human erythrocytes. Cell Physiol Biochem. 2017;41(2):731-741. PMID: 28222420.

Smith B, Randle D, Mezencev R, et al. Camalexin-induced apoptosis in prostate cancer cells involves alterations of expression and activity of lysosomal protease cathepsin D. Molecules. 2014 Apr 2;19(4):3988-4005. PMID: 24699144.

Smith B, Neal C, Chetram M, et al. The phytoalexin camalexin mediates cytotoxicity towards aggressive prostate cancer cells via reactive oxygen species. J Nat Med. 2013 Jul;67(3):607-618. PMID: 23179315.

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