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Carbenoxolone Disodium

Carbenoxolone Disodium

Product ID C0169
Cas No. 7421-40-1
Purity ≥97%
Product Unit SizeCostQuantityStock
1 g $75.30 In stock
5 g $217.90 In stock
25 g $716.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
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Description

Carbenoxolone disodium is a synthetic derivative of glycyrrhizin that exhibits anti-ulcerative, anti-inflammatory, neuromodulatory, neuroprotective, anti-hyperlipidemic, hepatoprotective, and immunosuppressive activities. Carbenoxolone is clinically used to treat ulcers and inflammation; it inhibits 11β-hydroxysteroid dehydrogenase as well as connexins, limiting gap junction communication. In animal models of cerebral ischemia/reperfusion, carbenoxolone decreases infarct volume and neuronal damage. Carbenoxolone also increases NO levels in other animal models, preventing gastric injury. In animal models of experimental autoimmune encephalitis (EAE), carbenoxolone delays disease onset and suppresses production of IL-23 and Th17 cells. In other animal models, this compound decreases levels of triglycerides, free fatty acids, SREBP-1c, LXR, and fatty acid synthase and suppresses hepatocyte apoptosis and inflammatory cytokine expression.

Product Info

Cas No.

7421-40-1

Purity

≥97%

Formula

C34H48Na2O7

Formula Wt.

614.70

Chemical Name

(3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean- 12-en-29-oic acid

IUPAC Name

disodium;(2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-(3-carboxylatopropanoyloxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylate

Synonym

18β-Glycyrrhetic acid hydrogen succinate, Carbenoxalone

Solubility

Soluble in water. Insoluble in chloroform.

Appearance

White or pale cream powder, hygroscopic

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C0169 MSDS PDF

Info Sheet

C0169 Info Sheet PDF

References

Song Z, Zhao C, Yan J, et al. Carbenoxolone disodium suppresses the migration of gastric cancer by targeting HDAC6. Future Med Chem. 2023 Feb;15(4):333-344. PMID: 36946221.

Chen G, Park CK, Xie RG, et al. Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice. Brain. 2014 Aug;137(Pt 8):2193-209. PMID: 24919967.

Beraki S, Litrus L, Soriano L, et al. A pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke. PLoS One. 2013 Jul 18;8(7):e69233. PMID: 23874920.

Rhee SD, Kim CH, Park JS, et al. Carbenoxolone prevents the development of fatty liver in C57BL/6-Lep ob/ob mice via the inhibition of sterol regulatory element binding protein-1c activity and apoptosis. Eur J Pharmacol. 2012 Sep 15;691(1-3):9-18. PMID: 22742899.

Endong L, Shijie J, Sonobe Y, et al. The gap-junction inhibitor carbenoxolone suppresses the differentiation of Th17 cells through inhibition of IL-23 expression in antigen presenting cells. J Neuroimmunol. 2011 Dec 15;240-241:58-64. PMID: 22036952.

Chávez-Piña AE, Tapia-Álvarez GR, Reyes-Ramínrez A, et al. Carbenoxolone gastroprotective mechanism: participation of nitric oxide/(c) GMP/K(ATP) pathway in ethanol-induced gastric injury in the rat. Fundam Clin Pharmacol. 2011 Dec;25(6):717-22. PMID: 21105909.

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