Catharanthine Tartrate

Name: Catharanthine Tartrate
SKU: C0378
Availability: InStock

Product ID C0378

Cas No. 4168-17-6

Purity ≥97%

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Description

Catharanthine is an alkaloid found in Catharanthus that is a chemical precursor in the synthesis of vinca alkaloids such as vinblastine and vincristine. Catharanthine displays weak anti-mitotic activity, binding tubulin poorly. Catharanthine exhibits anti-parasitic, vasodilatory, and antihypertensive activities. This compound shows antimalarial benefit against species of Plasmodium. In vivo, catharanthine inhibits voltage-gated Ca2+ channel currents, decreasing blood pressure and heart rate.

Product Info

Cas No.	4168-17-6
Purity	≥97%
Formula	C₂₁H₂₄N₂O₂ • C₄H₆O₆
Formula Wt.	486.52
Chemical Name	3,4-Didehydroibogamine-18-carboxylic acid methyl ester
IUPAC Name	2,3-dihydroxybutanedioic acid;methyl (1R,15R,18R)-17-ethyl-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4,6,8,16-pentaene-1-carboxylate
Synonym	Catharanthine
Melting Point	126-128°C
Solubility	Soluble in ethanol.
Appearance	White Powder

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	C0378 MSDS PDF
Info Sheet	C0378 Info Sheet PDF

References

Munigunti R, Becker K, Brun R, et al. Determination of antiplasmodial activity and binding affinity of selected natural products towards PfTrxR and PfGR. Nat Prod Commun. 2013 Aug;8(8):1135-6. PMID: 24079187.

Jadhav A, Liang W, Papageorgiou PC, et al. Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes. J Pharmacol Exp Ther. 2013 Jun;345(3):383-92. PMID: 23532933.

Sertel S, Fu Y, Zu Y, et al. Molecular docking and pharmacogenomics of vinca alkaloids and their monomeric precursors, vindoline and catharanthine. Biochem Pharmacol. 2011 Mar 15;81(6):723-35. PMID: 21219884.

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Catharanthine Tartrate

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Description

Product Info

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References

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