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Cisplatin

Cisplatin

Product ID C3374
Cas No. 15663-27-1
Purity ≥99%
Product Unit SizeCostQuantityStock
50 mg $50.00 In stock
100 mg $71.50 In stock
500 mg $214.70 In stock
1 g $350.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • Downloads
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Description

Cisplatin is a platinum-based cross-linking agent that exhibits anticancer chemotherapeutic activity. Cisplatin induces crosslinks between guanine bases on DNA; it is clinically used to treat various forms of cancer. In lung cancer cells, cisplatin decreases phosphorylation of PI3K, Akt, and FOXO3a and induces apoptosis. Additionally, cisplatin modulates STAT signaling and immune responses in other models.

 

Product Info

Cas No.

15663-27-1

Purity

≥99%

Formula

Cl2H6N2Pt

Formula Wt.

300.04

Chemical Name

cis-Dichlorodiammine platinum(II)

IUPAC Name

azanide;dichloroplatinum(2+)

Synonym

Abiplatin, DDP, Platiblastin, cis- Dichlorodi- ammineplatinum

Melting Point

270°C (dec.)

Solubility

Slightly soluble in water. Soluble in DMSO to 60mg/mL.

Appearance

Glassy yellow or orange, yellow crystalline powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C3374 MSDS PDF

Info Sheet

C3374 Info Sheet PDF

References

Hato SV, Khong A, de Vries IJ, et al. Molecular pathways: the immunogenic effects of platinum-based chemotherapeutics. Clin Cancer Res. 2014 Jun 1;20(11):2831-7. PMID: 24879823.

Liu H, Yin J, Wang C, et al. FOXO3a mediates the cytotoxic effects of cisplatin in lung cancer cells. Anticancer Drugs. 2014 Sep;25(8):898-907. PMID: 24814195.

Stordal B, Davey M. Understanding cisplatin resistance using cellular models. IUBMB Life. 2007 Nov;59(11):696-9. PMID: 17885832.

Marcon L, Zhang X, Hales BF, et al. Effects of chemotherapeutic agents for testicular cancer on rat spermatogonial stem/progenitor cells. J Androl. 2011 Jul-Aug;32(4):432-443. PMID: 21088230.

Custom Order

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