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Clemizole Hydrochloride

Clemizole Hydrochloride

Product ID C4418
Cas No. 1163-36-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $92.70 In stock
25 mg $337.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Clemizole is an inhibitor of transient receptor potential cation 5 (TRPC5) channels, NS4B, and histamine H1 receptors; it displays antiviral, anticonvulsant, anti-inflammatory, and anti-allergic activities. Clemizole suppresses replication of hepatitis C virus (HCV) and prevents convulsive behaviors and seizures in vivo.

Product Info

Cas No.

1163-36-6

Purity

≥98%

Formula

C19H20ClN3 • HCl

Formula Wt.

362.3

IUPAC Name

1-(4-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride (1:1)

Synonym

NSC46261 Hydrochloride, CID2782 Hydrochloride

Solubility

Soluble to 20 mM in water and to 50 mM in DMSO.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

C4418 MSDS PDF

Info Sheet

C4418 Info Sheet PDF

Brochures

TRP Channel Modulator Flyer

References

Richter JM, Schaefer M, Hill K. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. PMID: 25140002.

Baraban SC, Dinday MT, Hortopan GA. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat Commun. 2013;4:2410. PMID: 24002024.

Einav S, Sobol HD, Gehrig E, et al. The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. J Infect Dis. 2010 Jul 1;202(1):65-74. PMID: 20486856.

Martínez-Mir MI, Estañ L, Morales-Olivas FJ, et al. Effect of histamine and histamine analogues on human isolated myometrial strips. Br J Pharmacol. 1992 Oct;107(2):528-31. PMID: 1358393.

Custom Order

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