LKT Labs

Biochemicals for Life Science Research

Clofibric Acid

Clofibric Acid

Product ID C4556
Cas No. 882-09-7
Purity ≥98%
Product Unit SizeCostQuantityStock
10 g $52.00 In stock
50 g $83.00 In stock
Bulk Quote

Quicklinks

Description

Clofibric acid is a metabolite of clofibrate that activates PPARα receptors and inhibits auxin activity, exhibiting anti-hyperlipidemic, anti-angiogenic, anticancer chemotherapeutic, and herbicidal activity. Clofibric acid alters plant hormone activity and is used as a plant growth regulator. Clofibric acid also inhibits phosphatidylethanolamine synthesis, decreasing production of cholesterol and activity of HMG-CoA reductase and ACAT. Additionally, clofibric acid suppresses production of prostaglandin E2 (PGE2) and VEGF, decreases vessel density, and inhibits tumor growth in animal models of ovarian cancer.

Product Info

Cas No.

882-09-7
Purity

≥98%
Formula

C10H11ClO3
Formula Wt.

214.65
Chemical Name

2-(4-Chlorophenoxy)-2-methylpropanoic acid
IUPAC Name

2-(4-chlorophenoxy)-2-methylpropanoic acid
Synonym

Chlorfibrinic acid, Arteriohom, Regulipid
Melting Point

118-119°C

Appearance

Light Yellow Fine Crystalline Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

C4556 MSDS PDF
Info Sheet

C4556 Info Sheet PDF

References

Yokoyama Y, Xin B, Shigeto T, et al. Clofibric acid, a peroxisome proliferator-activated receptor alpha ligand, inhibits growth of human ovarian cancer. Mol Cancer Ther. 2007 Apr;6(4):1379-86. PMID: 17431116.

Nishimaki-Mogami T, Suzuki K, Okochi E, et al. Bezafibrate and clofibric acid are novel inhibitors of phosphatidylcholine synthesis via the methylation of phosphatidylethanolamine. Biochim Biophys Acta. 1996 Nov 11;1304(1):11-20. PMID: 8944746.

Haughom B, Spydevold O. The mechanism underlying the hypolipemic effect of perfluorooctanoic acid (PFOA), perfluorooctane sulphonic acid (PFOSA) and clofibric acid. Biochim Biophys Acta. 1992 Sep 22;1128(1):65-72. PMID: 1327145.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L1983

    Leucomyosuppressin

    Peptide found in insects.

    ≥95%
  • A5302

    Anastrozole

    Aromatase inhibitor.

    ≥99%
  • A4496

    Alyssin

    Naturally sourced ITC, sulfonyl analog of sulfo...

    ≥97%
  • L8248

    Lumiracoxib

    NSAID; COX-2 inhibitor.

    ≥98%
  • A0025

    17-Allylaminogeldanamycin

    Geldanamycin derivative; HSP90 inhibitor.

    ≥97%
  • M8007

    Mubritinib, Free Base

    EGFR2 inhibitor.

    ≥99%
  • C4000

    CK-636

    Arp2/3 inhibitor.

    ≥98%
  • C9612

    Cyclosporin C

    Cyclosporin metabolite; weak calmodulin inhibit...

    ≥98%
  • A4440

    Allicin

    Organosulfur found in garlic, binds DNA; inward...

    ≥98%
  • C0278

    (+)-Catechin

    Flavanol originally found in Camilla (green tea...

    ≥99%
  • P3440

    PIK-293

    p110δ PI3K inhibitor.

    ≥98%
  • Z4552

    ZLN005

    PPARγ coactivator-1α expression stimulator.

    ≥98%
  • D3462

    Diphenhydramine Hydrochloride

    Voltage-gated Na+ channel blocker, mAChR antago...

    ≥98%
  • T0152

    Tandutinib

    FLT3, PDGFR, c-Kit inhibitor.

    ≥98%
  • D1773

    Deshydroxy LY-411575

    γ-Secretase inhibitor.

    ≥98%
  • M3353

    Minocycline Hydrochloride

    Tetracycline; protein translation inhibitor, MM...

    ≥98%
  • E5200

    Enalaprilat Dihydrate

    Enalapril metabolite; ACE inhibitor.

    ≥98%
  • W317520

    WIN 55,212-2 Mesylate

    Non-selective cannabinoid receptor agonist.

    ≥98%
  • A0922

    Acetyl-L-Carnitine Hydrochloride

    Carnitine derivative, involved in energy homeos...

    ≥98%
  • P3542

    PIK-93

    p110α and p110γ PI3K inhibitor.

    ≥98%