LKT Labs

Biochemicals for Life Science Research

Clofibric Acid

Clofibric Acid

Product ID C4556
Cas No. 882-09-7
Purity ≥98%
Product Unit SizeCostQuantityStock
10 g $52.20 In stock
50 g $82.70 In stock
Bulk Quote

Quicklinks

Description

Clofibric acid is a metabolite of clofibrate that activates PPARα receptors and inhibits auxin activity, exhibiting anti-hyperlipidemic, anti-angiogenic, anticancer chemotherapeutic, and herbicidal activity. Clofibric acid alters plant hormone activity and is used as a plant growth regulator. Clofibric acid also inhibits phosphatidylethanolamine synthesis, decreasing production of cholesterol and activity of HMG-CoA reductase and ACAT. Additionally, clofibric acid suppresses production of prostaglandin E2 (PGE2) and VEGF, decreases vessel density, and inhibits tumor growth in animal models of ovarian cancer.

Product Info

Cas No.

882-09-7
Purity

≥98%
Formula

C10H11ClO3
Formula Wt.

214.65
Chemical Name

2-(4-Chlorophenoxy)-2-methylpropanoic acid
IUPAC Name

2-(4-chlorophenoxy)-2-methylpropanoic acid
Synonym

Chlorfibrinic acid, Arteriohom, Regulipid
Melting Point

118-119°C

Appearance

Light Yellow Fine Crystalline Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

C4556 MSDS PDF
Info Sheet

C4556 Info Sheet PDF

References

Yokoyama Y, Xin B, Shigeto T, et al. Clofibric acid, a peroxisome proliferator-activated receptor alpha ligand, inhibits growth of human ovarian cancer. Mol Cancer Ther. 2007 Apr;6(4):1379-86. PMID: 17431116.

Nishimaki-Mogami T, Suzuki K, Okochi E, et al. Bezafibrate and clofibric acid are novel inhibitors of phosphatidylcholine synthesis via the methylation of phosphatidylethanolamine. Biochim Biophys Acta. 1996 Nov 11;1304(1):11-20. PMID: 8944746.

Haughom B, Spydevold O. The mechanism underlying the hypolipemic effect of perfluorooctanoic acid (PFOA), perfluorooctane sulphonic acid (PFOSA) and clofibric acid. Biochim Biophys Acta. 1992 Sep 22;1128(1):65-72. PMID: 1327145.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T6903

    Tranylcypromine Hydrochloride

    MAO and histone demethylase LSD1 inhibitor.

    ≥98%
  • T0002

    T2 Toxin

    Trichothecene mycotoxin produced by Fusarium, a...

    ≥98%
  • B4974

    BMS-777607

    MET and Ron inhibitor.

    ≥99%
  • D1644

    Deltorphin I

    Opioid peptide; δOR agonist.

    ≥98%
  • B0108

    Bactenecin

    Cathelicidin derivative, antimicrobial peptide,...

    ≥95%
  • D1629

    Dehydroepiandrosterone

    Endogenous steroid hormone; ERβ, NMDA, σ1 ago...

    ≥98%
  • P1854

    Penicillic Acid

    Neuroactive mycotoxin produced by Penicillum an...

    ≥98%
  • A6804

    Arbutin

    Glycoside hydroquinone originally found in Berg...

    ≥98%
  • L0250

    Laminin Peptide SIKVAV

    Laminin-derived hexapeptide.

    ≥98%
  • T564092

    γ-Tocopherol

    Vitamin E component

    ≥98%
  • C1648

    α-Cembrenediol

    Diterpene found in Anisomeles.

    ≥99%
  • M1679

    Methysticin

    Kavalactone originally found in Piper methystic...

    ≥98%
  • S3368

    S1RA

    σ1 antagonist.

    ≥99%
  • C4533

    Clindamycin Phosphate

    Lincosamide; ribosomal translocation and protei...

    ≥98%
  • I7759

    Isoxanthohumol

    Prenylflavinoid, derivative of xanthohumol foun...

    ≥98%
  • L1784

    Levetiracetam

    SV2A synaptic vesicle inhibitor.

    ≥99%
  • A4844

    Amylin (8-37), human

    Endogenous peptide hormone inolved in gastric e...

    ≥95%
  • A7577

    Astilbin

    Flavonoid found in various plant sources.

    ≥99%
  • P0268

    Parasin I

    Histone H2-derived antimicrobial peptide found ...

    ≥95%
  • T5604

    Tobramycin, Free Base

    Aminoglycoside; protein translation inhibitor.<...

    ≥98%