LKT Labs

Biochemicals for Life Science Research

Clozapine N-oxide

Product ID C4759
Cas No. 34233-69-7
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $164.30 In stock
25 mg $576.50 In stock
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Description

Clozapine-N-oxide is a ligand that activates engineered GPCRs called “receptors activated solely by synthetic ligands” (RASSLs) or “designer receptors exclusively activated by designer drugs” (DREADDs); this allows for the studying of GPCR signaling control in vitro and in vivo. One example of these receptors is a mutated M3 muscarinic acetylcholine receptor (mAChR) that no longer responds to acetylcholine (ACh), only clozapine-N-oxide. Clozapine-N-oxide is otherwise pharmacologically inert.

Product Info

Cas No.

34233-69-7
Purity

≥98%
Formula

C18H19ClN4O
Formula Wt.

342.82
IUPAC Name

3-chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-5H-benzo[b][1,4]benzodiazepine
Synonym

CNO
Melting Point

212.0-214.0
Solubility

Water to 10 mM, DMSO to 10 mg/mL, acetone, ether, methanol.
Appearance

Yellow Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

C4759 MSDS PDF
Info Sheet

C4759 Info Sheet PDF

References

Li JH, Jain S, McMillin SM, et al. A novel experimental strategy to assess the metabolic effects of selective activation of a G(q)-coupled receptor in hepatocytes in vivo. Endocrinology. 2013 Oct;154(10):3539-51. PMID: 23861369.

Wess J, Nakajima K, Jain S. Novel designer receptors to probe GPCR signaling and physiology. Trends Pharmacol Sci. 2013 Jul;34(7):385-92. PMID: 23769625.

Farrell MS, Pei Y, Wan Y, et al. A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. Neuropsychopharmacology. 2013 Apr;38(5):854-62. PMID: 23303063.

Alvarez-Curto E, Prihandoko R, Tautermann CS, et al. Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL). Mol Pharmacol. 2011 Dec;80(6):1033-46. PMID: 21880827.

Francis TC, Chandra R, Friend DM, et al. Nucleus accumbens medium spiny neuron subtypes mediate depression-related outcomes to social defeat stress. Biol Psychiatry. 2015 Feb 1;77(3):212-222. PMID: 25173629.

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