LKT Labs

Biochemicals for Life Science Research

Clozapine

Clozapine

Product ID C4757
Cas No. 5786-21-0
Purity ≥97%
Product Unit SizeCostQuantityStock
25 mg $58.00 In stock
100 mg $97.00 In stock
250 mg $165.00 In stock
Bulk Quote

Quicklinks

Description

Clozapine is an atypical antipsychotic that also exhibits some immunosuppressive activity. Clozapine is clinically used to treat mood disorders. Clozapine binds Kv1.1 channels, prolonging the QT interval and also causes granulocytosis, limiting its clinical use. Clozapine acts as an antagonist at M1/2/3/5 muscarinic acetylcholine receptors (mAChRs) and D2 receptors, a partial agonist at 5-HT1A receptors, and as a full agonist at M4 mAChRs. Additionally, clozapine binds 5-HT2/3/6/7 receptors, D4 receptors, α1/2 adrenergic receptors, and histamine H1 receptors. Clozapine also potentiates GABAergic neurotransmission.

Product Info

Cas No.

5786-21-0
Purity

≥97%
Formula

C18H19ClN4
Formula Wt.

326.82
Chemical Name

8-chloro-11-(4-methyl-1-piperazinyl)-5H-Dibenzo(b,e)(1,4)diazepine

IUPAC Name

3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine
Synonym

Clozaril, Leponex
Melting Point

183-184°C
Solubility

Soluble in DMSO or dilute aqueous acid.

Appearance

Yellow crystalline powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

C4757 MSDS PDF
Info Sheet

C4757 Info Sheet PDF

References

Hill AP, Perrin MJ, Heide J, et al. Kinetics of drug interaction with the Kv11.1 potassium channel. Mol Pharmacol. 2014 May;85(5):769-76. PMID: 24586056.

Tanahashi S, Yamamura S, Nakagawa M, et al. Clozapine, but not haloperidol, enhances glial D-serine and L-glutamate release in rat frontal cortex and primary cultured astrocytes. Br J Pharmacol. 2012 Mar;165(5):1543-55. PMID: 21880034.

Wu Y, Blichowski M, Daskalakis ZJ, et al. Evidence that clozapine directly interacts on the GABAB receptor. Neuroreport. 2011 Sep 14;22(13):637-41. PMID: 21753741.

Nord M, Farde L. Antipsychotic occupancy of dopamine receptors in schizophrenia. CNS Neurosci Ther. 2011 Apr;17(2):97-103. PMID: 21143431.

Alvir JM, Lieberman JA, Safferman AZ, et al. Clozapine-induced agranulocytosis. Incidence and risk factors in the United States. N Engl J Med. 1993 Jul 15;329(3):162-7. PMID: 8515788.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M184770

    4-O-Methylhonokiol

    Found in Magnolia officinalis.

    ≥98%
  • G691343

    Griseofulvin

    Fungistatic

    ≥98%
  • I544766

    Intepirdine

    Selective 5-HT6 receptor antagonist

    ≥98%
  • B011460

    Baloxavir Marboxil

    Cap-dependent endonuclease inhibitor

    ≥ 99%
  • C1620

    Ceftiofur Hydrochloride

    β-lactam; penicillin binding protein inhibitor...

    ≥90%
  • C9880

    Cytochalasin C

    Mycotoxin produced by Aspergillus; actin polyme...

    ≥98%, TLC
  • A1202

    Adapalene

    Tretinoin analog; RARα/β/γ agonist.

    ≥98%
  • M0009

    Macitentan

    ET-A/B antagonist.

    ≥99%
  • M4000

    MK-2206 Monohydrochloride

    Akt inhibitor.

    ≥99%
  • T0394

    (+)-Taxifolin

    Catechol-type flavonoid; fatty acid synthesis i...

    ≥98%
  • F3473

    Fisetin

    Flavonoid found in various plant sources; matri...

    ≥97%
  • G7862

    GTPL-5846

    GPR84 agonist.

    ≥98%
  • I5208

    INCB-28060

    c-MET inhibitor.

    ≥98%
  • T1028

    Paclitaxel, 8-Hydro-bicyclo(3.3.0)octane

    Synthesis impurity

    ≥95%
  • E6814

    Erdosteine

    Thiol derivative, antioxidant.

    ≥98%
  • B030966

    BAY 11-7082

    inhibits inflammatory signaling

    ≥98%
  • R0154

    Ranolazine Dihydrochloride

    Nav1.7 and Nav1.8 N1+ channel blocker.

    ≥98%
  • G880000

    GW 405833

    Cannabinoid receptor 2 selective agonist.

    ≥98%
  • S8014

    Substance P, Free Acid

    Endogenous tachykinin peptide, involved in infl...

    ≥95%
  • T7135

    Triticonazole

    Triazole; 14-α demethylase inhibitor, potentia...

    ≥95%