• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Coptisine Chloride, synthetic

Coptisine Chloride, synthetic

Product ID C5864
Cas No. 6020-18-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $162.30 In stock
25 mg $382.90 In stock
100 mg $1,038.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Coptisine is an isoquinoline alkaloid originally found in a variety of sources, including species of Fumeria and Papavera. Coptisine exhibits a wide variety of beneficial properties, including cardioprotective, anti-inflammatory, neuromodulatory, antibacterial, and anticancer activities. Coptisine attenuates mitochondrial respiratory dysfunction, inhibits expression of RhoA and/or Rho-associated kinase (ROCK), and decreases myocardial apoptosis. Coptisine also inhibits proliferation of vascular smooth muscle cells, potentially through upregulation of Gadd45a and Rgc32 genes. Coptisine induces cell cycle arrest in vascular smooth muscle cells as well, decreasing levels of cyclin D1 and potentially inhibiting microtubule polymerization. In heart tissue, this compound inhibits expression of IL-6, TNF-α, and IL-1β, displaying cardioprotective benefit in animal models of ischemia/reperfusion. Coptisine inhibits proliferation in cancer cell lines. This compound also inhibits monoamine oxidase A (MAO-A) and exhibits antibiotic activity against gram negative bacteria Escherischia coli.

Product Info

Cas No.

6020-18-4

Purity

≥98%

Formula

C19H14ClNO4

Formula Wt.

355.77

Chemical Name

6,7-dihydro-[1,3]dioxolo[4',5':7,8]isoquinolino[3,2-a][1,3]dioxolo[4,5-g]isoquinolin-5-ium

IUPAC Name

5,7,17,19-tetraoxa-13-azoniahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-1(13),2,4(8),9,14,16(20),21,23-octaene;chloride

Solubility

DMSO:10mg/mL

Appearance

Orange Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C5864 MSDS PDF

Info Sheet

C5864 Info Sheet PDF

References

Guo J, Wang SB, Yuan TY, et al. Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation. Atherosclerosis. 2013 Dec;231(2):384-91. PMID: 24267256.

Gong LL, Fang LH, Wang SB, et al. Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats. Atherosclerosis. 2012 May;222(1):50-8. PMID: 22387061.

Suzuki H, Tanabe H, Mizukami H, et al. Differential gene expression in rat vascular smooth muscle cells following treatment with coptisine exerts a selective antiproliferative effect. J Nat Prod. 2011 Apr 25;74(4):634-8. PMID: 21401114.

Yan D, Jin C, Xiao XH, et al. Antimicrobial properties of berberines alkaloids in Coptis chinensis Franch by microcalorimetry. J Biochem Biophys Methods. 2008 Apr 24;70(6):845-9. PMID: 17804078.

Tanabe H, Suzuki H, Mizukami H, et al. Double blockade of cell cycle progression by coptisine in vascular smooth muscle cells. Biochem Pharmacol. 2005 Oct 15;70(8):1176-84. PMID: 16140275.

Lin CC, Ng LT, Hsu FF, et al. Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth. Clin Exp Pharmacol Physiol. 2004 Jan-Feb;31(1-2):65-9. PMID: 14756686.

Ro JS, Lee SS, Lee KS, et al. Inhibition of type A monoamine oxidase by coptisine in mouse brain. Life Sci. 2001 Dec 28;70(6):639-45. PMID: 11833714.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C9876

    CYT-387

    JAK2 inhibitor.

    ≥98%
  • I7759

    Isoxanthohumol

    Prenylflavinoid, derivative of xanthohumol foun...

    ≥98%
  • W2800

    WH-4-023

    Lck, Src, SIK inhibitor.

    ≥99 %
  • X1753

    Xenopsin

    Peptide hormone, neurotensin analog found in am...

    ≥95%
  • P3469

    Pirfenidone

    Collagen synthesis inhibitor.

    ≥98%
  • I0902

    Icaritin

    Flavonoid found in Epimedium.

    ≥98%
  • B6959

    Bromosporine

    BRD2/4/9 and CECR2 inhibitor.

    ≥99%
  • C4759

    Clozapine N-oxide

    Inert clozapine analog, activates specialized G...

    ≥98%
  • U7354

    Usnic Acid

    Dibenzofuran produced by lichens.

    ≥98%
  • C4274

    CKS-17

    Synthetic peptide, retroviral envelope protein ...

    ≥95%
  • C0022

    Cafestol Palmitate

    Diterpene found in brewed, unfiltered coffee; F...

    ≥97%
  • L1852

    Lenalidomide

    Thalidomide derivative; cereblon and TNF-α inh...

    ≥98%
  • L0211

    Lactulose

    Synthetic non-digestible disaccharide.

    ≥99%
  • B8274

    Buspirone Hydrochloride

    Azapirone; α1-adrenergic and 5-HT1A partial ag...

    ≥98%
  • A4496

    Alyssin

    Naturally sourced ITC, sulfonyl analog of sulfo...

    ≥97%
  • T6935

    Trimebutine Base

    BK K+ channel and L-type Ca2+ channel blocker.<...

    ≥97%
  • M5853

    Moniliformin sodium salt

    Mycotoxin produced by species of Fusarium; pote...

    ≥98%
  • S1604

    Secretin Acetate

    Endogenous peptide hormone, involved in feeding...

    ≥95%
  • M0374

    Masitinib

    PDGFR and c-Kit inhibitor.

    ≥99%
  • C2802

    CH5132799

    p110α PI3K inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only