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Corynoline is an alkaloid compound originally found in Corydalis tubers that exhibits anticancer activity. Corynoline displays cytotoxicity against several types of cancers in vitro, including lung carcinoma, colon carcinoma, melanoma, and ovarian carcinoma cell lines. Corynoline also noncompetitively inhibits acetylcholinesterase (AChE) in vitro.
| Cas No. | 18797-79-0 |
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| Purity | ≥98% |
| Formula | C21H21NO5 |
| Formula Wt. | 367.40 |
| Chemical Name | (1R,12S,13R)-13,24-dimethyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-2,4(8),9,14(22),15,17(21)-hexaen-12-ol |
| IUPAC Name | (1R,12S,13R)-13,24-dimethyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-2,4(8),9,14(22),15,17(21)-hexaen-12-ol |
| Synonym | 13-methylchelidonine |
| Appearance | White to off white powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Choi SU, Baek NI, Kim SH, et al. Cytotoxic isoquinoline alkaloids from the aerial parts of Corydalis incisa. Arch Pharm Res. 2007 Feb;30(2):151-4. PMID: 17366734.
Kim DK. Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase. Arch Pharm Res. 2002 Dec;25(6):817-9. PMID: 12510831.