Description
CX-6258 is an inhibitor of Pim kinase that exhibits anticancer chemotherapeutic activity. This compound decreases tumor growth in animal models of cancer.
CX-6258
Product ID C9200
Cas No. 1202916-90-2
Purity ≥98%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 1202916-90-2 |
|---|---|
| Purity | ≥98% |
| Formula | C26H24ClN3O3 |
| Formula Wt. | 461.95 |
| IUPAC Name | (3E)-5-Chloro-3-[(5-{3-[(4-methyl-1,4-diazepan-1-yl)carbonyl]phenyl}-2-furyl)methylene]-1,3-dihydro-2H-indol-2-one |
| Solubility | Water 89 mg/mL warmed (178.57 mM) DMSO 57 mg/mL warmed (114.36 mM) Ethanol 1 mg/mL warmed (2.0 mM) |
| Appearance | Light yellow solid |
Shipping and Storage
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Padmanabhan A, Gosc EB, Bieberich CJ. Stabilization of the prostate-specific tumor suppressor NKX3.1 by the oncogenic protein kinase Pim-1 in prostate cancer cells. J Cell Biochem. 2013 May;114(5):1050-7. PMID: 23129228.
Haddach M, Michaux J, Schwaebe MK, et al. Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor. ACS Med Chem Lett. 2011 Dec 27;3(2):135-9. PMID: 24900437.