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Cycloastragenol

Cycloastragenol

Product ID C9608
Cas No. 84605-18-5
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $82.00 In stock
100 mg $182.50 In stock
250 mg $319.00 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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Description

Cycloastragenol is a triterpene aglycone found in Radix Astragali (astragalus root). Cycloastragenol exhibits anti-fibrotic and anti-parasitic activities. In vitro, cycloastragenol increases phosphorylation of ERK, which may be dependent on Src and MEK signaling. Additionally, this compound activates telomerase ex vivo and in vivo, preventing the development of fibrosis and increasing epithelial life span; it is undergoing examination as a potential treatment for pulmonary fibrosis and other telomerase-associated disorders. Cycloastragenol may also inhibit activity of Trypanosoma parasites.

Product Info

Cas No.

84605-18-5

Purity

≥98%

Formula

C30H50O5

Formula Wt.

490.72

Chemical Name

(3β,6α,16β,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol

IUPAC Name

(1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-15-[(2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7,7,12,16-tetramethylpentacyclo[9.7.0.01,3.03,8.012,16]octadecane-6,9,14-triol

Synonym

Cyclogalagenin, Cyclogalegenin, Cyclogalegigenin

Melting Point

241-248°C

Solubility

Sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, first dissolve in DMF and then dilute with the aqueous buffer of choice. Cycloastragenol has a solubility of approximately 0.25 mg/ml in a 1:8 solution of DMF:PBS (pH 7.2) using this method.Solubility in DMSO is 98 mg/mL (199.7 mM)

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C9608 MSDS PDF

Info Sheet

C9608 Info Sheet PDF

References

Le Saux CJ, Davy P, Brampton C, et al. A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis. PLoS One. 2013;8(3):e58423. PMID: 23516479.

Yung LY, Lam WS, Ho MK, et al. Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types. Planta Med. 2012 Jan;78(2):115-21. PMID: 22083896.

Caliş I, Koyunoğlu S, Yeşilada A, et al. Antitrypanosomal cycloartane glycosides from Astragalus baibutensis. Chem Biodivers. 2006 Aug;3(8):923-9. PMID: 17193323.

Custom Order

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