LKT Labs

Biochemicals for Life Science Research

Cyclovirobuxine D

Cyclovirobuxine D

Product ID C9711
Cas No. 860-79-7
Purity ≥97%
Product Unit SizeCostQuantityStock
25 mg $128.00 In stock
100 mg $318.00 In stock
500 mg $1,086.00 In stock
Bulk Quote

Quicklinks

Description

Cyclovirobuxine D is originally found in Buxus and displays cardioprotective and anticancer activities. Cyclovirobuxine inhibits the viability of breast cancer cells, inhibiting phosphorylation of Akt and mTOR and inducing autophagy. This compound also shows benefit in the treatment of heart failure but may prolong the QT interval through inhibition of human ether-a-go-go-related (hERG) K+ channel currents. Additionally, cyclovirobuxine D decreases infarct size and venous thrombus size in animal models of myocardial ischemia.

Product Info

Cas No.

860-79-7
Purity

≥97%
Formula

C26H46N2O
Formula Wt.

402.66
IUPAC Name

C26H46N2O
Synonym

Bebuxine, Cyclovirobuxine
Melting Point

219-224°C
Appearance

White crystal

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

C9711 MSDS PDF
Info Sheet

C9711 Info Sheet PDF

References

Lu J, Sun D, Gao S, et al. Cyclovirobuxine D induces autophagy-associated cell death via the Akt/mTOR pathway in MCF-7 human breast cancer cells. J Pharmacol Sci. 2014;125(1):74-82. PMID: 24758922.

Yu B, Fang TH, Lü GH, et al. Beneficial effect of Cyclovirobuxine D on heart failure rats following myocardial infarction. Fitoterapia. 2011 Sep;82(6):868-77. PMID: 21575690.

Zhao J, Wang Q, Xu J, et al. Cyclovirobuxine D inhibits the currents of HERG potassium channels stably expressed in HEK293 cells. Eur J Pharmacol. 2011 Jun 25;660(2-3):259-67. PMID: 21497594.

Hu D, Liu X, Wang Y, et al. Cyclovirobuxine D ameliorates acute myocardial ischemia by K(ATP) channel opening, nitric oxide release and anti-thrombosis. Eur J Pharmacol. 2007 Aug 13;569(1-2):103-9. PMID: 17555743.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G0175

    Gastric Inhibitory Peptide, human

    Endogenous peptide hormone, somatostatin analog...

    ≥95%
  • A4443

    L-(+)-Alliin

    Optically active cysteine derivative found in A...

    ≥98%
  • D604080

    DpC

    Anti-metastatic

    ≥99%
  • E622698

    Eprosartan Mesylate

    Nonpeptide angiotensin II receptor antagonist

    ≥99%
  • N0161

    β-Naphthoflavone

    AhR agonist.

    ≥98%
  • L1981

    Leucokinin VIII

    Peptide found in insects.

    ≥95%
  • G0104

    Gabexate Mesylate

    Proteasome inhibitor.

    ≥99%
  • C4756

    Cloxacillin Sodium Monohydrate

    β-lactam; penicillin binding protein inhibitor...

    ≥98%
  • L9602

    LY-2874455

    FGFR inhibitor.

    ≥98%
  • G3359

    Ginkgolide J

    Terpene lactone found in Ginkgo.

    ≥98%
  • G733404

    GSK3685032

    Reversible DNMT1-selective inhibitor

    ≥98%
  • F5870

    N-formyl-Met-Leu-Phe

    Peptide, involved in neutrophil activation; FPR...

    ≥95%
  • R3321

    Rifaximin

    Rifampicin derivative; DNA-dependent RNA polyme...

    ≥98%
  • R2788

    RGW-611

    Morpholine derivative.

    ≥98%
  • A5302

    Anastrozole

    Aromatase inhibitor.

    ≥99%
  • A5070

    Angiotensin Acetate

    Peptide, derivative of AT I, cleavage product o...

    ≥95%
  • T5060

    TMP-269

    HDAC inhibitor.

    ≥98%
  • T5946

    Toltrazuril

    Coccidiostat; mitochondrial respiration inhibit...

    ≥98%
  • T5605

    Tobramycin Sulfate

    Aminoglycoside; protein translation inhibitor.<...

    ≥98%
  • G7346

    GSK-2636771

    p110β PI3K inhibitor.

    ≥98%