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Cytochalasin A

Cytochalasin A

Product ID C9878
Cas No. 14110-64-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $107.30 In stock
5 mg $461.50 In stock
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  • Description
  • Product Info
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  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Cytochalasin A is a mycotoxin actin polymerization inhibitor initially produced by species of Aspergillus. Cytochalasin A inhibits platelet-mediated adhesion of tumor cells to the endothelial matrix, displaying potential anticancer benefit. Cytochalasin A also inhibits Kv1.5 K+ channels in vitro. This compound’s disruption of actin polymerization also prevents phagocytosis in macrophages.

Product Info

Cas No.

14110-64-6

Purity

≥98%

Formula

C29H35NO5

Formula Wt.

477.60

IUPAC Name

(1S,4E,10R,12E,14S,15S,17S,18S,19S)-19-benzyl-15-hydroxy-10,17-dimethyl-16-methylidene-2-oxa-20-azatricyclo[12.7.0.01,18]henicosa-4,12-diene-3,6,21-trione

Synonym

Dehydrophomin

Melting Point

193-195°C

Appearance

White Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C9878 MSDS PDF

Info Sheet

C9878 Info Sheet PDF

References

Choi BH, Park JA, Kim KR, et al. Direct block of cloned hKv1.5 channel by cytochalasins, actin-disrupting agents. Am J Physiol Cell Physiol. 2005 Aug;289(2):C425-36. PMID: 15800051.

Menter DG, Sloane BF, Steinert BW, et al. Platelet enhancement of tumor cell adhesion to subendothelial matrix: role of platelet cytoskeleton and platelet membrane. J Natl Cancer Inst. 1987 Nov;79(5):1077-90. PMID: 3479634.

Custom Order

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