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Cytochalasin E

Cytochalasin E

Product ID C9882
Cas No. 36011-19-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $107.10 In stock
5 mg $447.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Cytochalasin E is a mycotoxin actin polymerization inhibitor initially produced by species of Aspergillus. Cytochalasin E increases levels of IL-8, ICAM-1, and CD-54 in vitro. Cytochalasin E also exhibits anticancer chemotherapeutic and anti-angiogenic activities. In endothelial cells, cytochalasin E inhibits cell proliferation and FGF-stimulated angiogenesis. In similar animal models, this compound inhibits lung tumor growth.

Product Info

Cas No.

36011-19-5

Purity

≥98%

Formula

C28H33NO7

Formula Wt.

495.57

IUPAC Name

(1S,5E,7R,9S,11E,13S,14S,16R,17S,18S,19S)-19-benzyl-7-hydroxy-7,9,16,17-tetramethyl-2,4,15-trioxa-20-azatetracyclo[11.8.0.01,18.014,16]henicosa-5,11-diene-3,8,21-trione

Melting Point

206°C (dec)

Appearance

White Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C9882 MSDS PDF

Info Sheet

C9882 Info Sheet PDF

References

Ikewaki N, Yamada A, Inoko H. Depolymerization of actin filament by cytochalasin E induces interleukin-8 production and up-regulates CD54 in the HeLa epithelial cell line. Microbiol Immunol. 2003;47(10):775-83. PMID: 14605444.

Udagawa T, Yuan J, Panigrahy D, et al. Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. J Pharmacol Exp Ther. 2000 Aug;294(2):421-7. PMID: 10900214.

Gan Y, Au JL, Lu J, et al. Antiproliferative and cytotoxic effects of geldanamycin, cytochalasin E, suramin and thiacetazone in human prostate xenograft tumor histocultures. Pharm Res. 1998 Nov;15(11):1760-6. PMID: 9834000.

Custom Order

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