• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Daidzein

Daidzein

Product ID D0032
Cas No. 486-66-8
Purity ≥97%
Product Unit SizeCostQuantityStock
250 mg $103.10 In stock
1 g $225.40 In stock
5 g $450.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Daidzein is a phytoestrogen and isoflavone initially found in various plant sources, including soybeans. Daidzein exhibits pro-fibrotic, anti-inflammatory, anticancer chemotherapeutic, neuroprotective, immunomodulatory, anti-osteoporotic, anti-resorptive, anti-obesity, and antioxidative activities. Daidzein increases collagen synthesis and inhibits collagen degradation in fibroblasts by activating TGF-β/Smad signaling. In vivo, daidzein decreases TNF-α-induced lung inflammation, expression of Cxcl2, activation of NF-κB, and activity of PARP-1. In hepatic cancer cells, daidzein induces apoptosis, increases cytochrome c release and activation of caspases 3 and 9, and decreases cellular proliferation. In other in vitro models, daidzein increases neurite growth by increasing activity of PKC, ERK, and Src. In vivo, daidzein decreases ovariectomy-induced increases in CD4+ T cell levels; it also increases CD28+ T cell levels, decreases RANKL expression, and suppresses osteoclast formation. This compound inhibits adipogenic differentiation by increasing lipolysis in vitro. In vivo, daidzein increases levels of superoxide dismutase, catalase, glutathione, glutathione peroxidase, and glutathione-S-transferase, inhibiting DMBA-induced breast cancer development.

Product Info

Cas No.

486-66-8

Purity

≥97%

Formula

C15H10O4

Formula Wt.

254.24

Chemical Name

7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

IUPAC Name

7-hydroxy-3-(4-hydroxyphenyl)chromen-4-one

Synonym

7,4'-Dihydroxyisoflavone

Melting Point

315-325°C(dec.)

Solubility

Soluble in ethanol or ether.

Appearance

Sliight Yellow Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D0032 MSDS PDF

Info Sheet

D0032 Info Sheet PDF

Brochures

Natural Products Booklet

References

Li HY, Pan L, Ke YS, et al. Daidzein suppresses pro-inflammatory chemokine Cxcl2 transcription in TNF-α-stimulated murine lung epithelial cells via depressing PARP-1 activity. Acta Pharmacol Sin. 2014 Apr;35(4):496-503. PMID: 24632845.

Zhao D, Shi Y, Dang Y, et al. Daidzein stimulates collagen synthesis by activating the TGF-β/smad signal pathway. Australas J Dermatol. 2014 Mar 19. [Epub ahead of print]. PMID: 24645968.

Park HJ, Jeon YK, You DH, et al. Daidzein causes cytochrome c-mediated apoptosis via the Bcl-2 family in human hepatic cancer cells. Food Chem Toxicol. 2013 Oct;60:542-9. PMID: 23959101.

Yanagihara K, Takigahira M, Mihara K, et al. Inhibitory effects of isoflavones on tumor growth and cachexia in newly established cachectic mouse models carrying human stomach cancers. Nutr Cancer. 2013;65(4):578-89. PMID: 23659450.

Yang SH, Liao CC, Chen Y, et al. Daidzein induces neuritogenesis in DRG neuronal cultures. J Biomed Sci. 2012 Aug 29;19:80. PMID: 22931352.

Tyagi AM, Srivastava K, Sharan K, et al. Daidzein prevents the increase in CD4+CD28null T cells and B lymphopoesis in ovariectomized mice: a key mechanism for anti-osteoclastogenic effect. PLoS One. 2011;6(6):e21216. PMID: 21731677.

Kim MH, Park JS, Seo MS, et al. Genistein and daidzein repress adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells via Wnt/β-catenin signalling or lipolysis. Cell Prolif. 2010 Dec;43(6):594-605. PMID: 21039998.

Mishra P, Kar A, Kale RK. Prevention of chemically induced mammary tumorigenesis by daidzein in pre-pubertal rats: the role of peroxidative damage and antioxidative enzymes. Mol Cell Biochem. 2009 May;325(1-2):149-57. PMID: 19214712.

Yokoyama S, Niwa T, Osawa T, Suzuki T. Characterization of an O-desmethylangolensin-producing bacterium isolated from human feces. Arch Microbiol. 2010 Jan;192(1):15-22. PMID: 19904524.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • N1721

    Nefiracetam

    Pyrrolidone; NMDA and mGluR5 agonist, N-type an...

    ≥98%
  • T5871

    Torin 2

    Tricyclic benzonaphthyridinone; mTORC1/2 inhibi...

    ≥98%
  • F0048

    Famciclovir

    Penciclovir prodrug, nucleoside (guanosine) ana...

    ≥98%
  • R2788

    RGW-611

    Morpholine derivative.

    ≥98%
  • L8277

    [Gln8]-Luteinizing Hormone Releasing Hormone, chicken

    Endogenous peptide hormone, involved in secreti...

    ≥95%
  • C4534

    Clindamycin Palmitate Hydrochloride

    Lincosamide; ribosomal translocation and protei...

    ≥98%
  • B7058

    Brompheniramine Maleate

    Pheniramine derivative; histamine H1 and mAChR ...

    ≥98%
  • N5210

    Nociceptin

    Endogenous neuropeptide, involved in opioid sig...

    ≥98%
  • A9662

    AZ-628

    B-Raf and c-Raf inhibitor.

    ≥96%
  • A7034

    Aripiprazole

    D2 and 5-HT1A partial agonist, 5-HT2C/6/7 antag...

    ≥98%
  • D3223

    Difloxacin Hydrochloride

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • E9819

    Ezetimibe

    NPC1L1 inhibitor.

    ≥99%
  • S0049

    Salmon Calcitonin Acetate

    Peptide, involved in feeding behavior and insul...

    ≥95%
  • M1976

    Methimazole

    Thioamide; thyroid peroxidase inhibitor.

    ≥98%
  • S0368

    Sarcophine

    Cembranoid diterpene found in Sarcophyton glauc...

    ≥98%
  • R0349

    Ramosetron

    5-HT3 antagonist.

    ≥99%
  • A0802

    Acarbose

    α-glucosidase inhibitor.

    ≥98%
  • A4402

    L-Alaninol

    Amino acid alcohol.

    ≥98%
  • A5228

    Angiogenin

    Small protein, cleaves RNA.

    ≥98%
  • B8274

    Buspirone Hydrochloride

    Azapirone; α1-adrenergic and 5-HT1A partial ag...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only