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Dapivirine

Dapivirine

Product ID D0261
Cas No. 244767-67-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $112.60 In stock
5 mg $245.10 In stock
25 mg $759.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Dapivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that is currently in clinical trials as a prophylactic against HIV infection. In various models such as dendritic cells and T cells, dapivirine exhibits antiviral activity by suppressing viral replication.

Product Info

Cas No.

244767-67-7

Purity

≥98%

Formula

C20H19N5

Formula Wt.

329.41

IUPAC Name

4-{[4-(Mesitylamino)-2-pyrimidinyl]amino}benzonitrile

Synonym

TMC120, R147681

Solubility

0.2mg/ml in DMSO and 0.3 mg/ml in DMF, sparingly soluble in aqueous buffers

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

D0261 MSDS PDF

Info Sheet

D0261 Info Sheet PDF

Brochures

Antivirals Booklet

References

Devlin B, Nuttall J, Wilder S, et al. Development of dapivirine vaginal ring for HIV prevention. Antiviral Res. 2013 Dec;100 Suppl:S3-8. PMID: 24188702.

Gupta SK, Nutan. Clinical use of vaginal or rectally applied microbicides in patients suffering from HIV/AIDS. HIV AIDS (Auckl). 2013 Oct 22;5:295-307. PMID: 24174883.

Njai HF, Lewi PJ, Janssen CG, et al. Pre-incubation of cell-free HIV-1 group M isolates with non-nucleoside reverse transcriptase inhibitors blocks subsequent viral replication in co-cultures of dendritic cells and T cells. Antivir Ther. 2005;10(2):255-62. PMID: 15865220.

Van Herrewege Y, Michiels J, Van Roey J, et al. In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides. Antimicrob Agents Chemother. 2004 Jan;48(1):337-9. PMID: 14693562.

Custom Order

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