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Dehydrocostus Lactone

Dehydrocostus Lactone

Product ID D1627
Cas No. 477-43-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $102.00 In stock
10 mg $173.70 In stock
25 mg $388.00 In stock
Bulk Quote

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  • Product Info
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  • Description
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Description

Dehydrocostus lactone (DHL) is a sesquiterpene lactone originally found in species of Saussurea. DHL exhibits antibiotic, antioxidative, anti-angiogenic, anticancer chemotherapeutic, and chemopreventive activities. DHL displays antibacterial activity against species of Mycobacterium. In osteoblasts, DHL increases levels of NADPH, thioredoxin reductase, and phospho-CREB and decreases levels of nitrotyrosin, preventing mitochondrial dysfunction induced by antimycin A. In macrophages treated with LPS, DHL decreases expression of iNOS and TNF-α. Additionally, DHL activates cAMP-activated cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels in thyroid cells. In vitro and in vivo, this compound downregulates expression of cyclin D1, Akt, mTOR, and inhibits phosphorylation of GSK-3β, inducing G0/G1 phase cell cycle arrest and preventing capillary tube formation. In soft tissue sarcoma cell lines, DHL decreases expression of CDK2, p27, CDK1/cdc2, cyclin B1, and matrix metalloproteinases 2 and 9 (MMP2/9), inducing G2/M phase cell cycle arrest and inhibiting cell proliferation.

Product Info

Cas No.

477-43-0

Purity

≥98%

Formula

C15H18O2

Formula Wt.

230.3

Chemical Name

(3aS,6aR,9aR,9bS)-3,6,9-trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[5,4-d]furan-2-one

IUPAC Name

(3aS,6aR,9aR,9bS)-3,6,9-trimethylidene-3a,4,5,6a,7,8,9a, 9b-octahydroazuleno[4,5-b]furan-2-one

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

D1627 MSDS PDF

Info Sheet

D1627 Info Sheet PDF

References

Wang X, Zhang YF, Yu B, et al. Dehydrocostuslactone, a sesquiterpene lactone activates wild-type and ΔF508 mutant CFTR chloride channel. J Asian Nat Prod Res. 2013;15(8):855-66. PMID: 23799322.

Lohberger B, Rinner B, Stuendl N, et al. Sesquiterpene lactones downregulate G2/M cell cycle regulator proteins and affect the invasive potential of human soft tissue sarcoma cells. PLoS One. 2013 Jun 14;8(6):e66300. PMID: 23799090.

Wang CY, Tsai AC, Peng CY, et al. Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathways. PLoS One. 2012;7(2):e31195. PMID: 22359572.

Seo MS, Choi EM. The effects of dehydrocostus lactone on osteoblastic MC3T3-E1 cells in redox changes and PI3K/Akt/CREB. Immunopharmacol Immunotoxicol. 2012 Oct;34(5):810-4. PMID: 22324303.

Choi EM. Dehydrocostus lactone prevents mitochondrial dysfunction in osteoblastic MC3T3-E1 cells. Eur J Pharmacol. 2011 Aug 16;664(1-3):1-7. PMID: 21596031.

Luna-Herrera J, Costa MC, González HG, et al. Synergistic antimycobacterial activities of sesquiterpene lactones from Laurus spp. J Antimicrob Chemother. 2007 Mar;59(3):548-52. PMID: 17218447.

Lee HJ, Kim NY, Jang MK, et al. A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-alpha in LPS-activated macrophages. Planta Med. 1999 Mar;65(2):104-8. PMID: 10193198.

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