Description
Demecolcine binds tubulin and induces microtubule depolymerization and prevents polymerization. Demecolcine forces ejection of the nucleus and is used in research models studying embryonic cloning.
Demecolcine
Product ID D1749
Cas No. 477-30-5
Purity ≥97%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 477-30-5 |
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| Purity | ≥97% |
| Formula | C21H25NO5 |
| Formula Wt. | 371.43 |
| Chemical Name | 6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)- benzo[a]heptalen-9(5H)-one |
| IUPAC Name | 1,2,3,10-tetramethoxy-7-(methylamino)-6, 7-dihydro-5H-benzo[a]heptalen-9-one |
| Synonym | N-methyl-N-desacetylcolchicine, Colcemid, Omaine |
| Melting Point | 186°C |
| Solubility | Soluble in alcohol, ether, chloroform, benzene or acidified water. |
| Appearance | Pale Yellow Powder |
Shipping and Storage
| Store Temp | 4°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Yang H, Ganguly A, Cabral F. Inhibition of cell migration and cell division correlates with distinct effects of microtubule inhibiting drugs. J Biol Chem. 2010 Oct 15;285(42):32242-50. PMID: 20696757.
Lan GC, Wu YG, Han D, et al. Demecolcine-assisted enucleation of goat oocytes: protocol optimization, mechanism investigation, and application to improve the developmental potential of cloned embryos. Cloning Stem Cells. 2008 Jun;10(2):189-202. PMID: 18373477.