Description
Demecolcine binds tubulin and induces microtubule depolymerization and prevents polymerization. Demecolcine forces ejection of the nucleus and is used in research models studying embryonic cloning.
| Product Unit Size | Cost | Quantity | Stock |
|---|
Demecolcine binds tubulin and induces microtubule depolymerization and prevents polymerization. Demecolcine forces ejection of the nucleus and is used in research models studying embryonic cloning.
| Cas No. | 477-30-5 |
|---|---|
| Purity | ≥97% |
| Formula | C21H25NO5 |
| Formula Wt. | 371.43 |
| Chemical Name | 6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)- benzo[a]heptalen-9(5H)-one |
| IUPAC Name | 1,2,3,10-tetramethoxy-7-(methylamino)-6, 7-dihydro-5H-benzo[a]heptalen-9-one |
| Synonym | N-methyl-N-desacetylcolchicine, Colcemid, Omaine |
| Melting Point | 186°C |
| Solubility | Soluble in alcohol, ether, chloroform, benzene or acidified water. |
| Appearance | Pale Yellow Powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Yang H, Ganguly A, Cabral F. Inhibition of cell migration and cell division correlates with distinct effects of microtubule inhibiting drugs. J Biol Chem. 2010 Oct 15;285(42):32242-50. PMID: 20696757.
Lan GC, Wu YG, Han D, et al. Demecolcine-assisted enucleation of goat oocytes: protocol optimization, mechanism investigation, and application to improve the developmental potential of cloned embryos. Cloning Stem Cells. 2008 Jun;10(2):189-202. PMID: 18373477.
α3β2, α3β4, α4β2 nAChR antagonist, indire...
Found in Colchicum; microtubule polymerization ...
Antioxidant, vitamin E derivative found in vege...
Imidazothiazole; alkaline phosphatase inhibitor...
GABA potentiator, voltage-gated Na+ and ATP-sen...
GABA analog; GABA potentiator, adenosine A1 ago...
PI3K inhibitor.
Cyclic tetrapeptide; HDAC inhibitor.
Nucleoside (cytidine) analog; RT and telomerase...
Nedd8-activating enzyme inhibitor.
Zinc chelator
Laminin-derived peptapeptide.
Purine (hypoxanthine) analog; xanthine oxidase ...
Amino sugar, sorbitol derivative, used as a bul...
Bioactive compound from olive tree.
NMDA NR1/NR2B antagonist.
Endogenous peptide hormone, involved in water h...
Amide form of vitamin B3 required for productio...
Endogenous peptide, involved in stress signalin...
COMT inhibitor.